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rdf:type |
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lifeskim:mentions |
umls-concept:C0013138,
umls-concept:C0015385,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0024660,
umls-concept:C0033713,
umls-concept:C0301560,
umls-concept:C0324348,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0521141,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1552599,
umls-concept:C1704787
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pubmed:issue |
1-2
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pubmed:dateCreated |
2001-1-26
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pubmed:databankReference |
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pubmed:abstractText |
We have isolated mammalian homologues of the Drosophila dachshund gene. Two domains of high conservation, one of which contains an alpha-helical, coiled-coil motif, show similarity to the Ski family of genes. We therefore propose that Dachshund belongs to a superfamily including these genes. Mouse Dachshund (Dach) is expressed in the eye and limb, structures affected by the Drosophila loss-of-function mutant, and rib primordia, CNS and genital eminence. Pax6 and Dach show overlapping but non-identical expression patterns. Dach expression is unaffected in smalleye mouse brain, indicating that Pax6 is not directly activating Dach. In Drosophila eye development dachshund is a component of an interacting network of proteins. Genes homologous to many of these exist in mammals; Dach joins this expanding group.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fetal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PAX6 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SKI protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ski protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/dachshund protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0925-4773
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1998 Elsevier Science Ireland Ltd. All rights reserved
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-31
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9651501-Amino Acid Sequence,
pubmed-meshheading:9651501-Animals,
pubmed-meshheading:9651501-Caenorhabditis elegans Proteins,
pubmed-meshheading:9651501-DNA, Complementary,
pubmed-meshheading:9651501-DNA-Binding Proteins,
pubmed-meshheading:9651501-Drosophila Proteins,
pubmed-meshheading:9651501-Drosophila melanogaster,
pubmed-meshheading:9651501-Expressed Sequence Tags,
pubmed-meshheading:9651501-Extremities,
pubmed-meshheading:9651501-Eye,
pubmed-meshheading:9651501-Eye Proteins,
pubmed-meshheading:9651501-Fetal Proteins,
pubmed-meshheading:9651501-Gene Expression Regulation, Developmental,
pubmed-meshheading:9651501-Genitalia,
pubmed-meshheading:9651501-Homeodomain Proteins,
pubmed-meshheading:9651501-Humans,
pubmed-meshheading:9651501-In Situ Hybridization,
pubmed-meshheading:9651501-Leg,
pubmed-meshheading:9651501-Mice,
pubmed-meshheading:9651501-Mice, Mutant Strains,
pubmed-meshheading:9651501-Molecular Sequence Data,
pubmed-meshheading:9651501-Morphogenesis,
pubmed-meshheading:9651501-Multigene Family,
pubmed-meshheading:9651501-Nerve Tissue Proteins,
pubmed-meshheading:9651501-Nervous System,
pubmed-meshheading:9651501-Nuclear Proteins,
pubmed-meshheading:9651501-Organ Specificity,
pubmed-meshheading:9651501-Paired Box Transcription Factors,
pubmed-meshheading:9651501-Protein Structure, Tertiary,
pubmed-meshheading:9651501-Proto-Oncogene Proteins,
pubmed-meshheading:9651501-Proto-Oncogenes,
pubmed-meshheading:9651501-Repressor Proteins,
pubmed-meshheading:9651501-Ribs,
pubmed-meshheading:9651501-Sequence Alignment,
pubmed-meshheading:9651501-Sequence Homology, Amino Acid,
pubmed-meshheading:9651501-Species Specificity
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pubmed:year |
1998
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pubmed:articleTitle |
Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb.
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pubmed:affiliation |
MRC-Human Genetics Unit, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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