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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5372
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pubmed:dateCreated |
1998-7-16
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pubmed:abstractText |
Hippocampal pyramidal cells are called place cells because each cell tends to fire only when the animal is in a particular part of the environment-the cell's firing field. Acute pharmacological blockade of N-methyl-D-aspartate (NMDA) glutamate receptors was used to investigate how NMDA-based synaptic plasticity participates in the formation and maintenance of the firing fields. The results suggest that the formation and short-term stability of firing fields in a new environment involve plasticity that is independent of NMDA receptor activation. By contrast, the long-term stabilization of newly established firing fields required normal NMDA receptor function and, therefore, may be related to other NMDA-dependent processes such as long-term potentiation and spatial learning.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2121-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9641919-Animals,
pubmed-meshheading:9641919-Brain Mapping,
pubmed-meshheading:9641919-Evoked Potentials,
pubmed-meshheading:9641919-Excitatory Amino Acid Antagonists,
pubmed-meshheading:9641919-Hippocampus,
pubmed-meshheading:9641919-Long-Term Potentiation,
pubmed-meshheading:9641919-Male,
pubmed-meshheading:9641919-Memory,
pubmed-meshheading:9641919-Neuronal Plasticity,
pubmed-meshheading:9641919-Piperazines,
pubmed-meshheading:9641919-Pyramidal Cells,
pubmed-meshheading:9641919-Rats,
pubmed-meshheading:9641919-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:9641919-Space Perception,
pubmed-meshheading:9641919-Time Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade.
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pubmed:affiliation |
Department of Physiology, SUNY Health Science Center Brooklyn, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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