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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1998-7-27
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pubmed:abstractText |
Morphogenesis of the insect kidney, the Malpighian tubules, is controlled in Drosophila by a single large cell, the tip cell. It has been postulated that this cell sends out a mitogenic signal that induces the division of neighboring cells. The signal and the molecules that receive it have remained elusive. We show that the COUP-TF-related nuclear orphan receptor Seven-up is a key component that becomes induced in response to mitogenic EGF receptor signaling activity emanating from the tip cell. Seven-up in turn is capable of regulating the transcription of cell cycle regulators.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-1326293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-1334894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-1365402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-1425358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-1606617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-1730394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-1733498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-2047861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-2105166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-2110920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-2199063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-7720557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-7789267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-7821213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-7867504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-7924981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-8156587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-8187637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-8223245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-8223268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-8269843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-8404527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-8521511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-8524239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-8674123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-8939845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-8951052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-9039257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-9053303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-9101138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-9154002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9637680-9262480
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/COUP Transcription Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Steroid,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/seven-up protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1781-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9637680-Animals,
pubmed-meshheading:9637680-COUP Transcription Factor I,
pubmed-meshheading:9637680-Cell Cycle,
pubmed-meshheading:9637680-Cell Division,
pubmed-meshheading:9637680-DNA-Binding Proteins,
pubmed-meshheading:9637680-Drosophila,
pubmed-meshheading:9637680-Eukaryotic Cells,
pubmed-meshheading:9637680-Gene Expression,
pubmed-meshheading:9637680-Gene Expression Regulation, Developmental,
pubmed-meshheading:9637680-Genes, Insect,
pubmed-meshheading:9637680-Insect Proteins,
pubmed-meshheading:9637680-Malpighian Tubules,
pubmed-meshheading:9637680-Mitogens,
pubmed-meshheading:9637680-Receptor, Epidermal Growth Factor,
pubmed-meshheading:9637680-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:9637680-Receptors, Steroid,
pubmed-meshheading:9637680-Signal Transduction,
pubmed-meshheading:9637680-Transcription Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney.
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pubmed:affiliation |
Max-Planck-Institut für Biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, 37077 Göttingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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