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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-7-6
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pubmed:databankReference |
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pubmed:abstractText |
We report the identification, characterization, and cloning of another novel Drosophila clock gene, cycle (cyc). Homozygous cyc flies are completely arrhythmic. Heterozygous cyc/+ flies are rhythmic but have altered periods, indicating that the cyc locus has a dosage effect on period. The molecular circadian phenotype of homozygous cyc flies is like homozygous Clk flies presented in the accompanying paper: mutant flies have little or no transcription of the per and tim genes. Cloning of the gene indicates that it also encodes a bHLH-PAS transcription factor and is a Drosophila homolog of the human protein BMAL1. cyc is a nonsense mutation, consistent with its strong loss-of-function phenotype. We propose that the CYC:CLK heterodimer binds to per and tim E boxes and makes a major contribution to the circadian transcription of Drosophila clock genes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ARNTL Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/ARNTL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PER protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Period Circadian Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/timeless protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
805-14
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9630224-ARNTL Transcription Factors,
pubmed-meshheading:9630224-Amino Acid Sequence,
pubmed-meshheading:9630224-Animals,
pubmed-meshheading:9630224-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:9630224-Behavior, Animal,
pubmed-meshheading:9630224-Chromosome Mapping,
pubmed-meshheading:9630224-Circadian Rhythm,
pubmed-meshheading:9630224-Cloning, Molecular,
pubmed-meshheading:9630224-Drosophila,
pubmed-meshheading:9630224-Drosophila Proteins,
pubmed-meshheading:9630224-Gene Dosage,
pubmed-meshheading:9630224-Genes, Insect,
pubmed-meshheading:9630224-Helix-Loop-Helix Motifs,
pubmed-meshheading:9630224-Insect Proteins,
pubmed-meshheading:9630224-Models, Genetic,
pubmed-meshheading:9630224-Molecular Sequence Data,
pubmed-meshheading:9630224-Mutation,
pubmed-meshheading:9630224-Nuclear Proteins,
pubmed-meshheading:9630224-Period Circadian Proteins,
pubmed-meshheading:9630224-Sequence Homology, Amino Acid,
pubmed-meshheading:9630224-Trans-Activators,
pubmed-meshheading:9630224-Transcription, Genetic,
pubmed-meshheading:9630224-Transcription Factors
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pubmed:year |
1998
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pubmed:articleTitle |
CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless.
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pubmed:affiliation |
NSF, Center for Biological Timing, and Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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