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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
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|
pubmed:dateCreated |
1998-8-24
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|
pubmed:abstractText |
Human recombinant interleukin-10 (rhIL-10) has been found to inhibit endotoxin-induced production of several proinflammatory cytokines including tumor necrosis factor alpha (TNFalpha) from human monocytes. The exogenous therapeutic administration of rhIL-10 in acute and chronic hyperinflammatory conditions has been discussed. For none of the large animal species that have been used to study the role and effects of various mediators during septicemia, crossreactivity of rhIL-10 has been shown so far. Therefore, the aim of the present investigation was to evaluate the crossreactivity of rhIL-10 in a porcine model.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0949-2321
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
17
|
|
pubmed:volume |
3
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
299-303
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|
pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9620892-Adjuvants, Immunologic,
pubmed-meshheading:9620892-Animals,
pubmed-meshheading:9620892-Humans,
pubmed-meshheading:9620892-Interleukin-10,
pubmed-meshheading:9620892-Lipopolysaccharides,
pubmed-meshheading:9620892-Lymphocyte Activation,
pubmed-meshheading:9620892-Monocytes,
pubmed-meshheading:9620892-Recombinant Proteins,
pubmed-meshheading:9620892-Swine,
pubmed-meshheading:9620892-Tumor Necrosis Factor-alpha
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
Recombinant human interleukin-10 attenuates TNFalpha production by porcine monocytes.
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|
pubmed:affiliation |
Institute of Anesthesiology, Klinikum Grosshadern, University of Munich, Marchioninistr. 15, D-81366 Munich, Germany.
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pubmed:publicationType |
Journal Article
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