Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-6-18
pubmed:abstractText
Enteric infections induce a response of circulating pathogen-specific antibody-secreting cells (ASC). The expression of homing receptors (HRs) on these cells was studied in patients with diarrhea caused by Vibrio cholerae in Bangladesh, an area in which cholera is endemic. The gut HR, alpha4beta7, was expressed by approximately 80% of the ASC, indicating mucosal homing of these cells. However, the peripheral lymph node HR, L-selectin, was also expressed by approximately 80% of the ASC specific to either cholera toxin or O antigen. In earlier findings after oral immunization in nonendemic areas, alpha4beta7 has been expressed by approximately 100% and L-selectin by approximately 50% of the ASC. In comparison, the present data speak for a more systemic targeting of the immune response associated with long-lasting immunity in an endemic area. The results thus provide insight for the continued development and evaluation of vaccines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
177
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1594-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9607838-Adolescent, pubmed-meshheading:9607838-Adult, pubmed-meshheading:9607838-Antibody-Producing Cells, pubmed-meshheading:9607838-Antigens, CD28, pubmed-meshheading:9607838-Cholera, pubmed-meshheading:9607838-Cholera Toxin, pubmed-meshheading:9607838-Diarrhea, pubmed-meshheading:9607838-Endemic Diseases, pubmed-meshheading:9607838-Follow-Up Studies, pubmed-meshheading:9607838-HLA-DR Antigens, pubmed-meshheading:9607838-Humans, pubmed-meshheading:9607838-India, pubmed-meshheading:9607838-Integrins, pubmed-meshheading:9607838-Intestinal Mucosa, pubmed-meshheading:9607838-L-Selectin, pubmed-meshheading:9607838-Lipopolysaccharides, pubmed-meshheading:9607838-Lymph Nodes, pubmed-meshheading:9607838-Male, pubmed-meshheading:9607838-Middle Aged, pubmed-meshheading:9607838-Vibrio cholerae
pubmed:year
1998
pubmed:articleTitle
Enteric infections in an endemic area induce a circulating antibody-secreting cell response with homing potentials to both mucosal and systemic tissues.
pubmed:affiliation
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't