Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-6-24
pubmed:abstractText
In a previous study, we demonstrated that by downregulating plasma membrane CD4 and increasing its processing, human immunodeficiency (HIV)-1-gp120 unveils hidden CD4 epitopes, inducing an in vitro anti-CD4-specific T-cell response. We report herein that this mechanism may potentially have important implications in HIV immunopathogenesis, because it could take part in the severe depletion of CD4+ cells that characterizes acquired immune deficiency syndrome (AIDS) and be related to disease progression. Freshly isolated peripheral blood lymphocytes (PBMC) from about 1/4 of a conspicuous cohort of HIV-infected patients responded to CD4 and this response was correlated with beta2-microglobulin levels, widely recognized as marker for progression of HIV infection. Moreover, we provide evidence that a CD4-specific T cell priming can occur in vivo, following a gp120 or anti-CD4 monoclonal antibody (mAb)-mediated CD4 molecule downregulation on antigen-presenting cells (APC). To our knowledge, this is the first study indicating that an autoimmune T-cell response is linked to HIV infection and that it could have an important impact on the immunopathogenesis of this disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0882-8245
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-17
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9586693-Adult, pubmed-meshheading:9586693-Antibodies, Monoclonal, pubmed-meshheading:9586693-Antigen-Presenting Cells, pubmed-meshheading:9586693-Antigens, CD4, pubmed-meshheading:9586693-Autoantibodies, pubmed-meshheading:9586693-Autoimmunity, pubmed-meshheading:9586693-CD4-Positive T-Lymphocytes, pubmed-meshheading:9586693-Down-Regulation, pubmed-meshheading:9586693-Female, pubmed-meshheading:9586693-HIV Envelope Protein gp120, pubmed-meshheading:9586693-HIV Infections, pubmed-meshheading:9586693-Histocompatibility Antigens Class II, pubmed-meshheading:9586693-Humans, pubmed-meshheading:9586693-Leukocytes, Mononuclear, pubmed-meshheading:9586693-Lymphocyte Activation, pubmed-meshheading:9586693-Male, pubmed-meshheading:9586693-Middle Aged, pubmed-meshheading:9586693-Tetanus Toxoid, pubmed-meshheading:9586693-Tuberculin
pubmed:year
1998
pubmed:articleTitle
Autoimmune T-cell response to the CD4 molecule in HIV-infected patients.
pubmed:affiliation
Istituto I Clinica Medica, Università di Roma La Sapienza, Rome, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't