Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1998-5-14
|
| pubmed:abstractText |
For this study, 188 bone marrow core biopsy specimens and aspirates analyzed morphologically and by flow cytometric immunophenotyping (FCI) in patients with a previous or new diagnosis of B-cell non-Hodgkin's lymphoma or mature B-cell leukemia were retrospectively reviewed to evaluate patterns of involvement and the usefulness of FCI. The morphologic and FCI results were categorized as follows: positive by morphologic examination and by FCI (39.9%); negative by morphologic examination and by FCI (41.5%); positive by morphologic examination and negative by FCI (11.7%); negative by morphologic examination and positive by FCI (2.6%); suggestive of malignant neoplasm by morphologic examination and positive by FCI (2.1%); and suggestive of malignant neoplasm by morphologic examination and negative by FCI (2.1%). Thus, in 81.4% of cases the morphologic and FCI findings were completely concordant. In 11.7% of cases, the morphologic examination alone detected involvement, and in 4.7% of cases, the FCI data detected involvement in a morphologically negative or "suggestive" bone marrow core. Combining these modalities is essential to evaluate bone marrow specimens for involvement by B-cell non-Hodgkin's lymphoma or B-cell leukemia.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0002-9173
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
109
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
625-30
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9576583-Antibodies, Monoclonal,
pubmed-meshheading:9576583-Biopsy, Needle,
pubmed-meshheading:9576583-Bone Marrow,
pubmed-meshheading:9576583-Flow Cytometry,
pubmed-meshheading:9576583-Humans,
pubmed-meshheading:9576583-Immunoglobulin gamma-Chains,
pubmed-meshheading:9576583-Immunoglobulin kappa-Chains,
pubmed-meshheading:9576583-Immunophenotyping,
pubmed-meshheading:9576583-Leukemia, B-Cell,
pubmed-meshheading:9576583-Lymphoma, B-Cell,
pubmed-meshheading:9576583-Retrospective Studies
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Combining morphology and flow cytometric immunophenotyping to evaluate bone marrow specimens for B-cell malignant neoplasms.
|
| pubmed:affiliation |
Department of Pathology, St Louis University Health Sciences Center, Missouri 63104, USA.
|
| pubmed:publicationType |
Journal Article
|