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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-5-7
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pubmed:abstractText |
Central tolerance depends upon Ag-mediated cell death in developing thymocytes. However, the mechanism of induced death is poorly understood. Among the known death-inducing proteins, TNF was previously found to be constitutively expressed in the thymus. The role of TNF in thymocyte negative selection was therefore investigated using TNF receptor (TNFR)-deficient mice containing a TCR transgene. TNFR-deficient mice displayed aberrant negative selection in two models: an in vitro system in which APC are cultured with thymocytes, and a popular in vivo system in which mice are treated with anti-CD3 Abs. In contrast, TNFR-deficient mice displayed normal thymocyte deletion in two Ag-induced in vivo models of negative selection. Current models of negative selection and the role of TNFR family members in this process are discussed in light of these results.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD30,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/H-Y Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
160
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
120-33
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9551964-Animals,
pubmed-meshheading:9551964-Antigen-Presenting Cells,
pubmed-meshheading:9551964-Antigens,
pubmed-meshheading:9551964-Antigens, CD3,
pubmed-meshheading:9551964-Antigens, CD30,
pubmed-meshheading:9551964-Antigens, CD40,
pubmed-meshheading:9551964-Cells, Cultured,
pubmed-meshheading:9551964-Clonal Deletion,
pubmed-meshheading:9551964-Female,
pubmed-meshheading:9551964-Flow Cytometry,
pubmed-meshheading:9551964-H-Y Antigen,
pubmed-meshheading:9551964-Histocompatibility Antigens Class II,
pubmed-meshheading:9551964-Lymph Nodes,
pubmed-meshheading:9551964-Lymphocyte Activation,
pubmed-meshheading:9551964-Male,
pubmed-meshheading:9551964-Mice,
pubmed-meshheading:9551964-Mice, Knockout,
pubmed-meshheading:9551964-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:9551964-Thymus Gland,
pubmed-meshheading:9551964-Tumor Necrosis Factor-alpha
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pubmed:year |
1998
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pubmed:articleTitle |
TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection.
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pubmed:affiliation |
Department of Biology and the Cancer Center, University of California-San Diego, La Jolla 92093-0687, USA. page@biomail.ucsd.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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