| pubmed-article:9551963 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9551963 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9551963 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:9551963 | lifeskim:mentions | umls-concept:C0162371 | lld:lifeskim |
| pubmed-article:9551963 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9551963 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:9551963 | lifeskim:mentions | umls-concept:C0221117 | lld:lifeskim |
| pubmed-article:9551963 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:9551963 | lifeskim:mentions | umls-concept:C0231204 | lld:lifeskim |
| pubmed-article:9551963 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9551963 | lifeskim:mentions | umls-concept:C1617068 | lld:lifeskim |
| pubmed-article:9551963 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9551963 | pubmed:dateCreated | 1998-5-7 | lld:pubmed |
| pubmed-article:9551963 | pubmed:abstractText | To determine whether human CD4+ T cells undergo post-thymic maturation, we compared the susceptibility to anergy induction in human thymic CD1a- CD4+ single-positive (CD4+), cord blood (CB) CD4+, and adult peripheral blood (APB) CD4+ T cells by stimulation with toxic shock syndrome toxin-1 (TSST-1). Most TSST-1-induced T cell blasts derived from either T cell preparation expressed TCR Vbeta2, which determines the potential reactivity to TSST-1. Most thymic CD4+ T cell blast preparations exhibited little or no production of IL-2 and IL-4 after restimulation with TSST-1 and only marginal responses after stimulation with rIL-2 or a combination of PMA and calcium ionophore, while the APB CD4+ T cell blasts showed high responses to these stimuli. The responses of CB CD4+ T cell blasts to these stimuli varied, ranging from minimal to relatively high. Studies of DNA fragmentation showed that there was no significant cell death of thymic CD4+ T cell blasts. Most thymic CD1a- CD4+ and CB CD4+ T cells were CD38 positive. APB CD4+ T cell blasts derived from the CD38+ fraction and from the CD38- fraction exhibited equally high responses to restimulation with TSST-1. These results indicate that thymic CD1a- CD4+ and CB CD4+ T cells are inherently highly susceptible to anergy induction by bacterial superantigens and that thymic CD1a- CD4+ T cells are less mature than CB CD4+ T cells, suggesting that post-thymic maturation in thymic T cells migrating to the periphery is required for acquisition of full reactivity to antigenic stimulation. | lld:pubmed |
| pubmed-article:9551963 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9551963 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9551963 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9551963 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9551963 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9551963 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9551963 | pubmed:author | pubmed-author:KatzEE | lld:pubmed |
| pubmed-article:9551963 | pubmed:author | pubmed-author:ImaiYY | lld:pubmed |
| pubmed-article:9551963 | pubmed:author | pubmed-author:UchiyamaTT | lld:pubmed |
| pubmed-article:9551963 | pubmed:author | pubmed-author:TakanashiYY | lld:pubmed |
| pubmed-article:9551963 | pubmed:author | pubmed-author:ImanishiKK | lld:pubmed |
| pubmed-article:9551963 | pubmed:author | pubmed-author:SeeEE | lld:pubmed |
| pubmed-article:9551963 | pubmed:author | pubmed-author:ZhangR HRH | lld:pubmed |
| pubmed-article:9551963 | pubmed:author | pubmed-author:Miyoshi-Akiya... | lld:pubmed |
| pubmed-article:9551963 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9551963 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9551963 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:9551963 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9551963 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9551963 | pubmed:pagination | 112-9 | lld:pubmed |
| pubmed-article:9551963 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9551963 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9551963 | pubmed:articleTitle | Post-thymic maturation of migrating human thymic single-positive T cells: thymic CD1a- CD4+ T cells are more susceptible to anergy induction by toxic shock syndrome toxin-1 than cord blood CD4+ T cells. | lld:pubmed |
| pubmed-article:9551963 | pubmed:affiliation | Department of Microbiology and Immunology, The Heart Institute of Japan, Tokyo Women's Medical College, Japan. | lld:pubmed |
| pubmed-article:9551963 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9551963 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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