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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1998-4-23
|
| pubmed:abstractText |
Recent clinical studies of Crohn's disease patients demonstrated dramatic clinical responses following one i.v. infusion of a chimeric mAb to TNF-alpha (cA2). To assess the role of TNF-alpha in mucosal cytokine regulation, the effects of TNF-alpha on lamina propria mononuclear cell (LPMC) Th1 production were determined. Increased IFN-gamma production was demonstrated in anti-CD2-stimulated LPMC cultured in TNF-alpha. To determine the effects of cA2 on cytokine production, TNF-alpha- and IFN-gamma-producing cells were quantitated in LPMC from five Crohn's disease patients treated with cA2. In all four patients who demonstrated clinical and endoscopic improvement, decreased numbers of LPMC producing IFN-gamma and TNF-alpha following CD2/CD28 activation paralleled improvement in disease activity over 8 wk. In one patient who did not improve, increased numbers of TNF-alpha- and IFN-gamma-secreting LPMC were observed. In three of four responding patients, CD2/CD28-activated PBMC demonstrated increased IFN-gamma production over 8 wk. These observations suggest that TNF-alpha may be a cofactor for mucosal Th1 responses, and improvement in clinical parameters and intestinal inflammation induced by cA2 in Crohn's disease may be mediated by down-regulation of mucosal Th1 cytokines.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
159
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6276-82
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9550432-Adjuvants, Immunologic,
pubmed-meshheading:9550432-Antibodies, Monoclonal,
pubmed-meshheading:9550432-Antigens, CD2,
pubmed-meshheading:9550432-Cell Count,
pubmed-meshheading:9550432-Cells, Cultured,
pubmed-meshheading:9550432-Coculture Techniques,
pubmed-meshheading:9550432-Crohn Disease,
pubmed-meshheading:9550432-Cytokines,
pubmed-meshheading:9550432-Dose-Response Relationship, Immunologic,
pubmed-meshheading:9550432-Humans,
pubmed-meshheading:9550432-Infusions, Intravenous,
pubmed-meshheading:9550432-Interferon-gamma,
pubmed-meshheading:9550432-Intestinal Mucosa,
pubmed-meshheading:9550432-Leukocytes, Mononuclear,
pubmed-meshheading:9550432-Lymphocyte Activation,
pubmed-meshheading:9550432-T-Lymphocyte Subsets,
pubmed-meshheading:9550432-Th1 Cells,
pubmed-meshheading:9550432-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease.
|
| pubmed:affiliation |
Cedars-Sinai Division of Gastroenterology, Inflammatory Bowel Disease Center, Los Angeles, CA 90048, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|