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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-5-14
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|
pubmed:abstractText |
Induction of mucosal as well as systemic immunity to HIV-1 is considered to have high priority in current concepts of future AIDS vaccines. Here we show that the desired immune responses can be elicited by an experimental prime-boost regimen consisting of mucosal (intragastric) application of a recombinant vaccinia virus carrying the HIV-1 env gene (vSC25), followed by parenteral (intradermal) immunization with the recombinant HIV-1 glycoprotein 160 (rgp160). Following intragastric immunization of mice with vSC25 in combination with the mucosal adjuvant cholera toxin (CT), HIV-1 env-specific IgA was secreted by B cells of Peyer's patches and the lamina propria. Moreover, mucosal (intragastric and intranasal) application of vSC25 (both in presence or absence of CT) induced a long-lasting, HIV-1 env-specific systemic cytotoxic T cell response. Subsequent intradermal boosters with rgp160 led to HIV-1-specific T cell memory and serum antibodies.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0889-2229
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
14
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
401-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9546799-AIDS Vaccines,
pubmed-meshheading:9546799-Animals,
pubmed-meshheading:9546799-Antibody Formation,
pubmed-meshheading:9546799-Cercopithecus aethiops,
pubmed-meshheading:9546799-Genes, env,
pubmed-meshheading:9546799-HIV Antibodies,
pubmed-meshheading:9546799-HIV Envelope Protein gp160,
pubmed-meshheading:9546799-HIV-1,
pubmed-meshheading:9546799-Humans,
pubmed-meshheading:9546799-Immunity, Cellular,
pubmed-meshheading:9546799-Immunity, Mucosal,
pubmed-meshheading:9546799-Immunization, Secondary,
pubmed-meshheading:9546799-Immunoglobulin A,
pubmed-meshheading:9546799-Immunoglobulin G,
pubmed-meshheading:9546799-Mice,
pubmed-meshheading:9546799-Mice, Inbred BALB C,
pubmed-meshheading:9546799-Recombinant Proteins,
pubmed-meshheading:9546799-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:9546799-Vaccination,
pubmed-meshheading:9546799-Vaccines, Synthetic,
pubmed-meshheading:9546799-Vero Cells
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pubmed:year |
1998
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|
pubmed:articleTitle |
An experimental prime-boost regimen leading to HIV type 1-specific mucosal and systemic immunity in BALB/c mice.
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pubmed:affiliation |
Department of Immunological Research, Immuno AG, Vienna, Austria.
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pubmed:publicationType |
Journal Article
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