Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-5-29
pubmed:databankReference
pubmed:abstractText
Although PTHrP is produced in multiple fetal tissues, its precise physiological functions have yet to be clearly elucidated. The present study was undertaken to elucidate the biological role of PTHrP in the development of tooth. In rat tooth germs, the PTHrP and its receptor genes were expressed in the enamel organ and dental mesenchyme, respectively. When mouse tooth explants were cultured with antisense oligodeoxyribonucleotides (ODN) against mouse PTHrP mRNA in serum-free medium, an invasion of bone tissue was observed in the tooth germs. On the other hand, the explants cultured without ODN or with sense ODN showed normal histological structures similar to those observed in vivo. These results suggest that PTHrP is essential for tooth development and for the protection of tooth germs from the invasion of bone tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0909-8836
pubmed:author
pubmed:issnType
Print
pubmed:volume
106 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9541217-Animals, pubmed-meshheading:9541217-Female, pubmed-meshheading:9541217-Gene Expression Regulation, Developmental, pubmed-meshheading:9541217-In Situ Hybridization, pubmed-meshheading:9541217-Mice, pubmed-meshheading:9541217-Mice, Inbred ICR, pubmed-meshheading:9541217-Molar, pubmed-meshheading:9541217-Molecular Sequence Data, pubmed-meshheading:9541217-Odontogenesis, pubmed-meshheading:9541217-Oligonucleotides, Antisense, pubmed-meshheading:9541217-Parathyroid Hormone-Related Protein, pubmed-meshheading:9541217-Pregnancy, pubmed-meshheading:9541217-Proteins, pubmed-meshheading:9541217-RNA, Messenger, pubmed-meshheading:9541217-Rats, pubmed-meshheading:9541217-Rats, Sprague-Dawley, pubmed-meshheading:9541217-Receptor, Parathyroid Hormone, Type 1, pubmed-meshheading:9541217-Receptors, Parathyroid Hormone, pubmed-meshheading:9541217-Tooth Germ
pubmed:year
1998
pubmed:articleTitle
Developmental role of PTHrP in murine molars.
pubmed:affiliation
Department of Oral Anatomy and Developmental Biology, Osaka University Faculty of Dentistry, Yamadaoka, Suita, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't