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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-4-13
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pubmed:databankReference |
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pubmed:abstractText |
Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, binds to two receptor tyrosine kinases, KDR/Flk-1 and Flt-1. We now describe the purification and the expression cloning from tumor cells of a third VEGF receptor, one that binds VEGF165 but not VEGF121. This isoform-specific VEGF receptor (VEGF165R) is identical to human neuropilin-1, a receptor for the collapsin/semaphorin family that mediates neuronal cell guidance. When coexpressed in cells with KDR, neuropilin-1 enhances the binding of VEGF165 to KDR and VEGF165-mediated chemotaxis. Conversely, inhibition of VEGF165 binding to neuropilin-1 inhibits its binding to KDR and its mitogenic activity for endothelial cells. We propose that neuropilin-1 is a novel VEGF receptor that modulates VEGF binding to KDR and subsequent bioactivity and therefore may regulate VEGF-induced angiogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropilin-1,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Mitogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vascular Endothelial...,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
735-45
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9529250-Antigens, Surface,
pubmed-meshheading:9529250-Cell Line,
pubmed-meshheading:9529250-Chemotaxis,
pubmed-meshheading:9529250-Cloning, Molecular,
pubmed-meshheading:9529250-Endothelial Growth Factors,
pubmed-meshheading:9529250-Endothelium, Vascular,
pubmed-meshheading:9529250-Exons,
pubmed-meshheading:9529250-Gene Expression,
pubmed-meshheading:9529250-Humans,
pubmed-meshheading:9529250-Isomerism,
pubmed-meshheading:9529250-Lymphokines,
pubmed-meshheading:9529250-Molecular Sequence Data,
pubmed-meshheading:9529250-Neovascularization, Physiologic,
pubmed-meshheading:9529250-Nerve Tissue Proteins,
pubmed-meshheading:9529250-Neuropilin-1,
pubmed-meshheading:9529250-RNA, Messenger,
pubmed-meshheading:9529250-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:9529250-Receptors, Growth Factor,
pubmed-meshheading:9529250-Receptors, Mitogen,
pubmed-meshheading:9529250-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:9529250-Recombinant Fusion Proteins,
pubmed-meshheading:9529250-Umbilical Cord,
pubmed-meshheading:9529250-Vascular Endothelial Growth Factor A,
pubmed-meshheading:9529250-Vascular Endothelial Growth Factors
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pubmed:year |
1998
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pubmed:articleTitle |
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.
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pubmed:affiliation |
Department of Surgery, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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