Source:http://linkedlifedata.com/resource/umls/id/C0100804
MSH: Dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and axonal guidance. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS, and binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.,NCI: Encoded by human NRP1 Gene (Neuropilin Family), Neuropilin 1 contains 1 MAM, 2 F5/8 type C, and 2 CUB domains. Found in embryonic nervous system, and adult heart, placenta lung, liver, skeletal muscle, kidney, and pancreas, type I membrane-bound 923-aa 103-kDa (precursor) isoform 1, expressed by blood vessels, acts as a receptor in cardiovascular development, angiogenesis, formation of neuronal circuits, and organogenesis. Binding to semaphorin 3A,