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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-4-16
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pubmed:abstractText |
We report a 20-month-old boy with acute lymphoblastic leukemia with the 11q23 translocation whose blasts markedly increased in peripheral blood after intravenous granulocyte colony-stimulating factor (G-CSF) administration, but disappeared after stopping G-CSF. The in vitro study showed that the leukemic cells separated from this patient expressed G-CSF receptor (G-CSFR) and an addition of G-CSF stimulated their proliferation by 3H-thymidine incorporation assay (stimulation index, 4.9). To clarify whether or not leukemic cells with 11q23 translocations generally express G-CSFR and show proliferative response to G-CSF, we performed the similar in vitro experiments using eight leukemic cell lines with 11q23 translocations. We found that all cell lines examined expressed G-CSFR (20-98%) and proliferation of seven leukemic cell lines was significantly enhanced in response to G-CSF (stimulation index >1.5 in five cell lines), suggesting a possible participation of the G-CSF/G-CSFR interaction in the process of growth regulation of leukemic cells with 11q23 translocations.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0887-6924
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pubmed:author |
pubmed-author:GohJJ,
pubmed-author:IijimaKK,
pubmed-author:InukaiTT,
pubmed-author:KagamiKK,
pubmed-author:KinoshitaAA,
pubmed-author:KojikaSS,
pubmed-author:MoriTT,
pubmed-author:NakazawaSS,
pubmed-author:O-KoyamaTT,
pubmed-author:SugitaKK,
pubmed-author:SuzukiTT,
pubmed-author:TezukaTT
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
382-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9529133-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9529133-B-Lymphocytes,
pubmed-meshheading:9529133-Blast Crisis,
pubmed-meshheading:9529133-Cell Division,
pubmed-meshheading:9529133-Cell Line,
pubmed-meshheading:9529133-Chromosome Mapping,
pubmed-meshheading:9529133-Chromosomes, Human, Pair 11,
pubmed-meshheading:9529133-Cytarabine,
pubmed-meshheading:9529133-DNA Replication,
pubmed-meshheading:9529133-Etoposide,
pubmed-meshheading:9529133-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:9529133-Granulocytes,
pubmed-meshheading:9529133-Humans,
pubmed-meshheading:9529133-Immunophenotyping,
pubmed-meshheading:9529133-Infant,
pubmed-meshheading:9529133-Male,
pubmed-meshheading:9529133-Mitoxantrone,
pubmed-meshheading:9529133-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:9529133-Receptors, Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:9529133-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
Leukemic cells with 11q23 translocations express granulocyte colony-stimulating factor (G-CSF) receptor and their proliferation is stimulated with G-CSF.
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pubmed:affiliation |
Department of Pediatrics, Yamanashi Medical University, Japan.
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pubmed:publicationType |
Journal Article,
Case Reports
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