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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-5-4
|
| pubmed:databankReference | |
| pubmed:abstractText |
Smallminded (smid) encodes a new member of the cdc48p/VCP subfamily of AAA proteins in Drosophila. The gene was isolated by plasmid rescue from a GAL4 enhancer trap line which shows reporter gene expression in neuroblasts, imaginal disks and a subset of sensory neurons. Larvae homozygous for the insert arrest development as second instar larvae and die without pupating. The most obvious defect in these larvae is a significantly reduced CNS, hence the naming of the gene as smallminded. The deduced amino acid sequence of smid contains a tandem duplication of the AAA nucleotide binding domain characteristic of the cdc48p/VCP subfamily. Overall, smid shares 33% identical residues with its closest relative, yeast L0919-chrXII and 26-29% with other members of the cdc48p/VCP subfamily. The most highly conserved regions of the predicted protein structure are found in and around the nucleotide binding domains. The gene is expressed at all developmental stages.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0378-1119
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
27
|
| pubmed:volume |
208
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
191-9
|
| pubmed:dateRevised |
2009-9-29
|
| pubmed:meshHeading |
pubmed-meshheading:9524263-Amino Acid Sequence,
pubmed-meshheading:9524263-Animals,
pubmed-meshheading:9524263-Base Sequence,
pubmed-meshheading:9524263-Brain,
pubmed-meshheading:9524263-Cell Cycle Proteins,
pubmed-meshheading:9524263-Cloning, Molecular,
pubmed-meshheading:9524263-Drosophila,
pubmed-meshheading:9524263-Drosophila Proteins,
pubmed-meshheading:9524263-Genes, Insect,
pubmed-meshheading:9524263-Genes, Reporter,
pubmed-meshheading:9524263-Heterozygote,
pubmed-meshheading:9524263-Homozygote,
pubmed-meshheading:9524263-Larva,
pubmed-meshheading:9524263-Molecular Sequence Data,
pubmed-meshheading:9524263-Neurons, Afferent,
pubmed-meshheading:9524263-Recombinant Fusion Proteins,
pubmed-meshheading:9524263-Sequence Alignment,
pubmed-meshheading:9524263-Sequence Homology, Amino Acid
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Isolation and characterisation of smallminded, a Drosophila gene encoding a new member of the Cdc48p/VCP subfamily of AAA proteins.
|
| pubmed:affiliation |
School of Biological Sciences, Division of Cell Sciences, University of Southampton, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|