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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-4-30
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pubmed:abstractText |
The effect of gender and concomitant use of contraceptive steroids on the absorption and metabolism of oxybutynin was investigated in 49 healthy volunteers, 24 females and 25 males. Serum concentrations of oxybutynin and its active metabolite, N-desethyloxybutynin, were measured for up to 48 h after ingestion of a single dose of 10 mg oxybutynin.
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Demographic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Europe,
http://linkedlifedata.com/resource/pubmed/keyword/FINLAND,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Human Volunteers,
http://linkedlifedata.com/resource/pubmed/keyword/Northern Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Population,
http://linkedlifedata.com/resource/pubmed/keyword/Population Characteristics,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Scandinavia,
http://linkedlifedata.com/resource/pubmed/keyword/Sex Factors
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0031-6970
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
351-4
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pubmed:dateRevised |
2004-11-17
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pubmed:otherAbstract |
PIP: This is a study of the effect of gender and concomitant use of contraceptive steroids on the absorption and metabolism of oxybutynin, a commonly used anticholinergic agent. 49 healthy volunteers--25 males and 24 females (13 using contraceptive steroids)--were given a single dose of 10 mg oxybutynin, which was ingested under standardized conditions. The serum concentrations of oxybutynin and its active metabolite, N-desethyloxybutynin, were then measured for up to 48 hours after ingestion. Results showed that concomitant use of contraceptive steroids had no significant effect on the pharmacokinetic parameters of oxybutynin or its metabolite. Neither was there any significant difference in its concentration between the male and female participants. Therefore, the pharmacokinetics of orally administered oxybutynin are unaffected by either gender or contraceptive steroids.
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pubmed:meshHeading |
pubmed-meshheading:9516036-Administration, Oral,
pubmed-meshheading:9516036-Adult,
pubmed-meshheading:9516036-Area Under Curve,
pubmed-meshheading:9516036-Cholinergic Antagonists,
pubmed-meshheading:9516036-Contraceptives, Oral, Hormonal,
pubmed-meshheading:9516036-Drug Interactions,
pubmed-meshheading:9516036-Female,
pubmed-meshheading:9516036-Humans,
pubmed-meshheading:9516036-Male,
pubmed-meshheading:9516036-Mandelic Acids,
pubmed-meshheading:9516036-Sex Factors
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pubmed:year |
1998
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pubmed:articleTitle |
The pharmacokinetics of oxybutynin is unaffected by gender and contraceptive steroids.
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pubmed:affiliation |
Department of Clinical Pharmacology, University of Helsinki, Haartmaninkatu, Finland.
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pubmed:publicationType |
Journal Article
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