pubmed-article:9512492 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9512492 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
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pubmed-article:9512492 | lifeskim:mentions | umls-concept:C0526260 | lld:lifeskim |
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pubmed-article:9512492 | lifeskim:mentions | umls-concept:C1428360 | lld:lifeskim |
pubmed-article:9512492 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
pubmed-article:9512492 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
pubmed-article:9512492 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
pubmed-article:9512492 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
pubmed-article:9512492 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
pubmed-article:9512492 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
pubmed-article:9512492 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
pubmed-article:9512492 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
pubmed-article:9512492 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
pubmed-article:9512492 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
pubmed-article:9512492 | pubmed:dateCreated | 1998-5-13 | lld:pubmed |
pubmed-article:9512492 | pubmed:abstractText | The CCAAT-binding factor CBF is a heterotrimeric transcription factor that specifically binds to CCAAT sequences in many eukaryotic genes. Previous studies have shown that CBF contains two transcription activation domains: a glutamine-rich, serine-threonine-rich domain present in the CBF-B subunit and a glutamine-rich domain in the CBF-C subunit. In this study, by using a series of deletion mutations of CBF-B and CBF-C in transcription assay in vitro, we further delineated smaller segments in these domains that were sufficient to support transcriptional activation by CBF. To test whether transcription activation by CBF requires co-activators, we examined the interaction between CBF and dTAF110, a component of the Drosophila TFIID complex. Recent work has demonstrated that glutamine-rich domains of the Sp1 transcription factor interact with dTAF110 and that this interaction has an important role in mediating transcription activation. Here we first demonstrate in a direct interaction assay in vitro that CBF binds dTAF110. By using a yeast two-hybrid system we show that both of the transcription activation domains of CBF interact with dTAF110. A deletion analysis suggests that a segment of CBF-B needed for transcription activation is also involved in interaction with dTAF110. In CBF-C the C-terminal portion of the molecule seems to be needed for these two activities. Our results suggest that TAF110 might represent one of the co-activators that mediate transcriptional activation by CBF. | lld:pubmed |
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pubmed-article:9512492 | pubmed:language | eng | lld:pubmed |
pubmed-article:9512492 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9512492 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:9512492 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9512492 | pubmed:month | Apr | lld:pubmed |
pubmed-article:9512492 | pubmed:issn | 0264-6021 | lld:pubmed |
pubmed-article:9512492 | pubmed:author | pubmed-author:SinhaSS | lld:pubmed |
pubmed-article:9512492 | pubmed:author | pubmed-author:CoustryFF | lld:pubmed |
pubmed-article:9512492 | pubmed:author | pubmed-author:MaityS NSN | lld:pubmed |
pubmed-article:9512492 | pubmed:author | pubmed-author:CrombruggheBB | lld:pubmed |
pubmed-article:9512492 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9512492 | pubmed:day | 1 | lld:pubmed |
pubmed-article:9512492 | pubmed:volume | 331 ( Pt 1) | lld:pubmed |
pubmed-article:9512492 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9512492 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9512492 | pubmed:pagination | 291-7 | lld:pubmed |
pubmed-article:9512492 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:9512492 | pubmed:meshHeading | pubmed-meshheading:9512492-... | lld:pubmed |
pubmed-article:9512492 | pubmed:year | 1998 | lld:pubmed |
pubmed-article:9512492 | pubmed:articleTitle | The two activation domains of the CCAAT-binding factor CBF interact with the dTAFII110 component of the Drosophila TFIID complex. | lld:pubmed |
pubmed-article:9512492 | pubmed:affiliation | Department of Molecular Genetics, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX77030, USA. | lld:pubmed |
pubmed-article:9512492 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9512492 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
entrez-gene:39765 | entrezgene:pubmed | pubmed-article:9512492 | lld:entrezgene |
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