Source:http://linkedlifedata.com/resource/umls/id/C0076919
MSH: The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.,NCI: TFIID is a DNA-binding protein complex required for RNA polymerase II-mediated transcription of many, if not all, protein-encoding genes in eukaryotic cells. TFIID plays a key role in initiation, since it binds to the TATA element to form a complex that nucleates the assembly of the other components into a preinitiation complex. TFIID interacts with TFIIA, which may stabilize its binding. A reinitiation intermediate including TFIID can act as a scaffold for formation of a functional reinitiation complex. TFIID also links the control of transcription to the cell cycle. The DNA-binding subunit of TFIID is the TATA box-binding protein (TBP) that interacts p