| pubmed-article:9512110 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9512110 | lifeskim:mentions | umls-concept:C0040732 | lld:lifeskim |
| pubmed-article:9512110 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9512110 | lifeskim:mentions | umls-concept:C0021852 | lld:lifeskim |
| pubmed-article:9512110 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:9512110 | lifeskim:mentions | umls-concept:C0018133 | lld:lifeskim |
| pubmed-article:9512110 | lifeskim:mentions | umls-concept:C0079717 | lld:lifeskim |
| pubmed-article:9512110 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:9512110 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9512110 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9512110 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9512110 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9512110 | pubmed:dateCreated | 1998-4-8 | lld:pubmed |
| pubmed-article:9512110 | pubmed:abstractText | Experimental graft-versus-host disease (GVHD) causes immune-mediated intestinal injury. The adhesion molecule lymphocyte function associated antigen-1 (LFA-1) is involved in leukocyte homing to areas of inflammatory injury. Our hypothesis was that LFA-1 is increased in the GVHD injured small bowel and colon. We found that animals with GVHD caused by auxiliary small bowel transplantation displayed significantly increased expression of intestinal LFA-1alpha at times of clinical illness when compared to controls. The staining pattern progressed from a few discretely stained cells in the lamina propria on day 5 to diffuse confluent staining of lamina propria on day 13 and was statistically significantly increased from controls at days 10 and 13. CyA-treated animals had intermediate staining between control and day 13 GVHD animals. There was no difference between sham-operated control animals and SBTx animals with GVHD in the amount of staining for LFA-1 in extraintestinal organs normally affected by GVHD. We conclude that: (1) LFA-1 expression in the small bowel and colon progressively increased during GVHD after SBTx; and (2) CyA treatment is associated with decreased LFA-1 expression in the small bowel and colon of GVHD animals after SBTx. LFA-1 may play an important role in immune-mediated injury of the intestine. | lld:pubmed |
| pubmed-article:9512110 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9512110 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9512110 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9512110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9512110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9512110 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9512110 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9512110 | pubmed:issn | 0163-2116 | lld:pubmed |
| pubmed-article:9512110 | pubmed:author | pubmed-author:RuggieriF SFS | lld:pubmed |
| pubmed-article:9512110 | pubmed:author | pubmed-author:PorterJ CJC | lld:pubmed |
| pubmed-article:9512110 | pubmed:author | pubmed-author:KoltunW AWA | lld:pubmed |
| pubmed-article:9512110 | pubmed:author | pubmed-author:OltG JGJ | lld:pubmed |
| pubmed-article:9512110 | pubmed:author | pubmed-author:ColonyPP | lld:pubmed |
| pubmed-article:9512110 | pubmed:author | pubmed-author:TilbergA FAF | lld:pubmed |
| pubmed-article:9512110 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9512110 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:9512110 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9512110 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9512110 | pubmed:pagination | 221-8 | lld:pubmed |
| pubmed-article:9512110 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:meshHeading | pubmed-meshheading:9512110-... | lld:pubmed |
| pubmed-article:9512110 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9512110 | pubmed:articleTitle | Increased LFA-1 expression in intestines of rats with GVHD after small bowel transplantation. | lld:pubmed |
| pubmed-article:9512110 | pubmed:affiliation | Department of Surgery, Pennsylvania State University, College of Medicine, The Milton S. Hershey Medical Center, Hershey 17033-0850, USA. | lld:pubmed |
| pubmed-article:9512110 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9512110 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
