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pubmed-article:9507890pubmed:abstractTextPhosphodiesterases (PDE) are key enzymes in the regulation of the smooth muscle tone. Experimental studies showed PDE III and V-isoenzymes to play an important role in the smooth muscle tone regulation of corpus cavernosum. Recently, a specific PDE III-inhibitor (milrinone) and a PDE V-inhibitor (sildenafil) were introduced in clinical studies. An experimental study was done to examine a potential role of PDE-inhibitors in the treatment of erectile dysfunction.lld:pubmed
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pubmed-article:9507890pubmed:articleTitleThe effect of the specific phosphodiesterase (PDE) inhibitors on human and rabbit cavernous tissue in vitro and in vivo.lld:pubmed
pubmed-article:9507890pubmed:affiliationDept. of Urology, Medizinische Hochschule Hannover, Germany.lld:pubmed
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