Linked Life Data

9506010

Source:http://linkedlifedata.com/resource/pubmed/id/9506010

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1998-3-30
pubmed:abstractText
Twenty healthy volunteers (age ranging from 19 to 72) were studied for their aldosterone response to oral administration of 10 mg cisapride, a serotonin-4 receptor agonist. The participants were studied after minimum of 4-hour ambulation (high basal renin) and a repeated test after overnight bed rest (low basal renin). Oral administration of cisapride caused a two-fold increase in the plasma aldosterone levels (182.6 +/- 28.0% in high renin state and 203.4 +/- 38.6% in low renin state; P = 0.659 between the means of two states) without affecting the plasma renin levels, Scatterplot of percentile aldosterone increment against age distribution demonstrated that the R-square were very low (0.039 for high renin and 0.009 for low renin state). Our data suggest that the age does not alter the serotonergic mediated effect on aldosterone secretion. The cisapride effect is also independent of the different basal renin states. Cisapride, as a single oral dose, could serve as a simple test to assess the functional capacity of aldosterone secretion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0091-2700
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1146-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effect of cisapride, a serotonin-4 receptor agonist, on aldosterone secretion: absence of age-related change.
pubmed:affiliation
Division of Endocrinology and Metabolism, Chang-Gung Memorial Hospital Medical Center, Tao-Yuan Hsien, Taiwan.
pubmed:publicationType
Journal Article