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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1998-2-18
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pubmed:abstractText |
The incidence of acute rejection and the morbidity of systemic cyclosporine (INN: cyclosporine) after lung transplantation is significant. Experimental evidence suggests that the allograft locally modulates the immune mechanisms of acute rejection. The purpose of this study was to determine whether aerosolized cyclosporine would prevent acute cellular rejection, achieve effective graft concentrations with low systemic drug delivery, and locally affect production of the inflammatory cytokines involved in acute rejection.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-5223
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28-36; discussion 36-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9451042-Administration, Inhalation,
pubmed-meshheading:9451042-Aerosols,
pubmed-meshheading:9451042-Animals,
pubmed-meshheading:9451042-Cyclosporine,
pubmed-meshheading:9451042-Cytokines,
pubmed-meshheading:9451042-Graft Rejection,
pubmed-meshheading:9451042-Immunosuppressive Agents,
pubmed-meshheading:9451042-Lung,
pubmed-meshheading:9451042-Lung Transplantation,
pubmed-meshheading:9451042-Polymerase Chain Reaction,
pubmed-meshheading:9451042-Rats,
pubmed-meshheading:9451042-Rats, Inbred ACI,
pubmed-meshheading:9451042-Rats, Inbred Lew
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pubmed:year |
1998
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pubmed:articleTitle |
Aerosol cyclosporine prevents acute allograft rejection in experimental lung transplantation.
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pubmed:affiliation |
Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, PA 15261, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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