| pubmed-article:9435511 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9435511 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9435511 | lifeskim:mentions | umls-concept:C1706383 | lld:lifeskim |
| pubmed-article:9435511 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:9435511 | lifeskim:mentions | umls-concept:C1531432 | lld:lifeskim |
| pubmed-article:9435511 | lifeskim:mentions | umls-concept:C0034815 | lld:lifeskim |
| pubmed-article:9435511 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:9435511 | lifeskim:mentions | umls-concept:C0085940 | lld:lifeskim |
| pubmed-article:9435511 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:9435511 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:9435511 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9435511 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:9435511 | pubmed:issue | 6 Pt 1 | lld:pubmed |
| pubmed-article:9435511 | pubmed:dateCreated | 1998-2-9 | lld:pubmed |
| pubmed-article:9435511 | pubmed:abstractText | We examined whether histamine could regulate cell proliferation and expression of the early response gene c-fos in HEK-293 cells stably transfected with the human H2 receptor (HEK-H2). Histamine stimulated [3H]thymidine incorporation [50% effective concentration (EC50) = 3.6 x 10(-6) M] in HEK-H2 cells in a cimetidine-sensitive manner and increased c-fos mRNA in a time-dependent fashion, reaching maximal induction after 30 min. Histamine induced luciferase activity in HEK-H2 cells transiently transfected with a construct containing the luciferase reporter gene (Luc) coupled to the serum response element (SRE) of the c-fos gene promoter (EC50 = 1.5 x 10(-6) M) or a plasmid containing the SRE core fragment (bases -320 to -298). The protein kinase C (PKC) inhibitor staurosporine and long-term pretreatment of HEK cells with phorbol ester inhibited the effect of histamine on PKC activation, SRE-Luc activity, and [3H]thymidine incorporation. We have demonstrated that activation of the human H2 receptor can lead to induction of c-fos gene transcription and cell proliferation through a PKC-dependent mechanism. | lld:pubmed |
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| pubmed-article:9435511 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9435511 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9435511 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9435511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9435511 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9435511 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9435511 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9435511 | pubmed:author | pubmed-author:WangMM | lld:pubmed |
| pubmed-article:9435511 | pubmed:author | pubmed-author:TodiscoAA | lld:pubmed |
| pubmed-article:9435511 | pubmed:author | pubmed-author:ButlerKK | lld:pubmed |
| pubmed-article:9435511 | pubmed:author | pubmed-author:HaraFF | lld:pubmed |
| pubmed-article:9435511 | pubmed:author | pubmed-author:WangL DLD | lld:pubmed |
| pubmed-article:9435511 | pubmed:author | pubmed-author:Del ValleJJ | lld:pubmed |
| pubmed-article:9435511 | pubmed:author | pubmed-author:HoeltzelMM | lld:pubmed |
| pubmed-article:9435511 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9435511 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9435511 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9435511 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9435511 | pubmed:pagination | C2037-45 | lld:pubmed |
| pubmed-article:9435511 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9435511 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9435511 | pubmed:articleTitle | Activation of the human histamine H2 receptor is linked to cell proliferation and c-fos gene transcription. | lld:pubmed |
| pubmed-article:9435511 | pubmed:affiliation | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA. | lld:pubmed |
| pubmed-article:9435511 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9435511 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9435511 | lld:pubmed |
