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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1998-2-3
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pubmed:abstractText |
E-selectin mediates neovascularization via its soluble form, while its membrane-bound form initiates binding of tumor cells to vascular endothelium. Therefore, it was studied whether soluble E-selectin regulates further adhesion molecules on tumor cells. In tumor cells but not in related nonmalignant cells, intercellular adhesion molecule (ICAM)-1 expression was strikingly increased from 5 to 68% positive cells by in vitro inoculation of a recombinant E-selectin-IgG1 within 24 h, as analyzed by flow cytometry. The absence of changes in the expression of vascular cell adhesion molecule, integrin ligands (CD11a, CD18, integrin alpha 4), and sialyl-Lewis X indicates a specific effect of soluble E-selectin on ICAM-1. A cell adhesion assay revealed that the enhanced adhesion on T-cells to tumor cells mediated by soluble E-selectin-induced ICAM-1 expression was at a maximum after a 12-h incubation period. Therefore, ICAM-1 regulation on tumor cells might be a mechanism of immune escape.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-4827
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
|
pubmed:volume |
237
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
364-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9434632-Cell Adhesion,
pubmed-meshheading:9434632-E-Selectin,
pubmed-meshheading:9434632-Gene Expression,
pubmed-meshheading:9434632-Humans,
pubmed-meshheading:9434632-Intercellular Adhesion Molecule-1,
pubmed-meshheading:9434632-Neoplasm Invasiveness,
pubmed-meshheading:9434632-RNA, Messenger,
pubmed-meshheading:9434632-Solubility,
pubmed-meshheading:9434632-T-Lymphocytes,
pubmed-meshheading:9434632-Time Factors,
pubmed-meshheading:9434632-Tumor Cells, Cultured,
pubmed-meshheading:9434632-Up-Regulation
|
pubmed:year |
1997
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pubmed:articleTitle |
Soluble E-selectin enhances intercellular adhesion molecule-1 (ICAM-1) expression in human tumor cell lines.
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pubmed:affiliation |
First Department of Internal Medicine, Johannes Gutenberg-University of Mainz, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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