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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1998-3-5
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pubmed:databankReference |
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pubmed:abstractText |
We describe the molecular characterization of the paired-type homeobox gene D-Ptx1 of Drosophila, a close homolog of the mouse pituitary homeobox gene Ptx1 and the unc-30 gene of C. elegans, characterized by a lysine residue at position 9 of the third alpha-helix of the homeodomain. D-Ptx1 is expressed at various restricted locations throughout embryogenesis. Initial expression of D-Ptx1 in the posterior-most region of the blastoderm embryo is controlled by fork head activity in response to the activated Ras/Raf signaling pathway. During later stages of embryonic development. D-Ptx1 transcripts and protein accumulate in the posterior portion of the midgut, in the developing Malpighian tubules, in a subset of ventral somatic muscles, and in neural cells. Phenotypic analysis of gain-of-function and lack-of-function mutant embryos show that the D-Ptx1 gene is not involved in morphologically apparent differentiation processes. We conclude that D-Ptx1 is more likely to control physiological cell functions than pattern formation during Drosophila embryogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0925-4773
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
139-47
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9431811-Amino Acid Sequence,
pubmed-meshheading:9431811-Animals,
pubmed-meshheading:9431811-Animals, Genetically Modified,
pubmed-meshheading:9431811-Blastoderm,
pubmed-meshheading:9431811-Body Patterning,
pubmed-meshheading:9431811-Drosophila,
pubmed-meshheading:9431811-Drosophila Proteins,
pubmed-meshheading:9431811-Embryo, Nonmammalian,
pubmed-meshheading:9431811-Forkhead Transcription Factors,
pubmed-meshheading:9431811-Gene Expression Regulation, Developmental,
pubmed-meshheading:9431811-Homeodomain Proteins,
pubmed-meshheading:9431811-Molecular Sequence Data,
pubmed-meshheading:9431811-Nuclear Proteins,
pubmed-meshheading:9431811-Paired Box Transcription Factors,
pubmed-meshheading:9431811-Phenotype,
pubmed-meshheading:9431811-Sequence Homology, Amino Acid,
pubmed-meshheading:9431811-Transcription, Genetic,
pubmed-meshheading:9431811-Transcription Factors
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pubmed:year |
1997
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pubmed:articleTitle |
Embryonic expression and characterization of a Ptx1 homolog in Drosophila.
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pubmed:affiliation |
Max-Planck-Institut für biophysikalische Chemie, Abt. Molekulare Entwicklungsbiologie, Am Fassberg, Göttingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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