Linked Life Data

9429852

Source:http://linkedlifedata.com/resource/pubmed/id/9429852

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-1-29
pubmed:abstractText
During human embryonic development the process of differentiation begins in the cells covering the blastocyst, resulting in the formation of outer syncytial and inner cytotrophoblastic cell layers. Although the outer syncytial layer is known to be derived from the underlying layer of mononuclear cytotrophoblasts, the cellular mechanism involved in its morphogenesis is not clear. Furthermore, there is another type of cells, designated as intermediate trophoblasts, which play a vital role in syncytium formation. Using early first-trimester (6-10 weeks' gestation) human chorionic villi, a study was carried out to illustrate the ultrastructural features of these cells. It was observed that while there was a large number of coated vesicles, vacuoles, lysosomes and dense granules in the syncytiotrophoblast, in cytotrophoblasts there was a relatively smaller number. In intermediate cells, however, these organelles were more abundant. Moreover, a discontinuity in the plasma membrane along with gap junctions was frequently observed in these cells. Since these features represent the transitional stage of a differentiating cell, it is possible that the syncytiotrophoblast is in fact formed by the differentiation of intermediate trophoblasts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1354-4195
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Ultrastructure of intermediate trophoblast cells during morphogenesis of syncytiotrophoblast in early human pregnancy.
pubmed:affiliation
Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't