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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1998-2-2
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pubmed:databankReference |
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pubmed:abstractText |
LIN-12/NOTCH proteins mediate cell-cell interactions that specify cell fates. Previous work suggested that sup-17 facilitates lin-12 signalling in Caenorhabditis elegans. Here, we show that sup-17 encodes a member of the ADAM family of metalloproteases. SUP-17 is highly similar to Drosophila KUZBANIAN, which functions in Drosophila neurogenesis, and the vertebrate ADAM10 protein. Furthermore, we show by genetic analysis that the extracellular domain of LIN-12 appears to be necessary for sup-17 to facilitate lin-12 signalling and that sup-17 does not act downstream of lin-12. Finally, we show by cell ablation experiments that sup-17 can act cell autonomously to facilitate lin-12 activity. We discuss the implications of our observations for LIN-12/NOTCH signalling and how our results complement and extend results obtained from genetic analysis of kuz in Drosophila.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADAM Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ADAM10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid Precursor Protein Secretases,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Disintegrins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lin-12 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/kuzbanian protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/notch protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0950-1991
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4759-67
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9428412-ADAM Proteins,
pubmed-meshheading:9428412-Amino Acid Sequence,
pubmed-meshheading:9428412-Amyloid Precursor Protein Secretases,
pubmed-meshheading:9428412-Animals,
pubmed-meshheading:9428412-Base Sequence,
pubmed-meshheading:9428412-Caenorhabditis elegans,
pubmed-meshheading:9428412-Caenorhabditis elegans Proteins,
pubmed-meshheading:9428412-Chromosome Mapping,
pubmed-meshheading:9428412-Conserved Sequence,
pubmed-meshheading:9428412-Disintegrins,
pubmed-meshheading:9428412-Drosophila,
pubmed-meshheading:9428412-Drosophila Proteins,
pubmed-meshheading:9428412-Helminth Proteins,
pubmed-meshheading:9428412-Humans,
pubmed-meshheading:9428412-Membrane Proteins,
pubmed-meshheading:9428412-Metalloendopeptidases,
pubmed-meshheading:9428412-Molecular Sequence Data,
pubmed-meshheading:9428412-Mutation,
pubmed-meshheading:9428412-Receptors, Notch,
pubmed-meshheading:9428412-Sequence Analysis, DNA,
pubmed-meshheading:9428412-Signal Transduction
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pubmed:year |
1997
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pubmed:articleTitle |
SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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