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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-3-30
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pubmed:abstractText |
Previous genetic studies of intersegmental nerve b development have identified several cell-surface proteins required for correct axon guidance to appropriate target muscles. Here we provide evidence that the small GTPase Drac1 also plays a key role in this guidance process. Neuronal expression of the dominant negative mutation Drac1(N17) causes axons to bypass and extend beyond normal synaptic partners. This phenotype is consistently reproduced by pharmacological blockade of actin assembly. Genetic interactions between Drac1(N17) and the receptor-tyrosine phosphatase Dlar suggest that intersegmental nerve b guidance requires the integration of multiple, convergent signals.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochalasin D,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Rac1 protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor-Like Protein Tyrosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/beat-Ia protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0950-1991
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
453-61
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9425140-Actins,
pubmed-meshheading:9425140-Animals,
pubmed-meshheading:9425140-Axons,
pubmed-meshheading:9425140-Cell Movement,
pubmed-meshheading:9425140-Central Nervous System,
pubmed-meshheading:9425140-Cytochalasin D,
pubmed-meshheading:9425140-Drosophila,
pubmed-meshheading:9425140-Drosophila Proteins,
pubmed-meshheading:9425140-GTP Phosphohydrolases,
pubmed-meshheading:9425140-GTP-Binding Proteins,
pubmed-meshheading:9425140-Genes, Dominant,
pubmed-meshheading:9425140-Motor Neurons,
pubmed-meshheading:9425140-Muscles,
pubmed-meshheading:9425140-Mutation,
pubmed-meshheading:9425140-Nerve Tissue Proteins,
pubmed-meshheading:9425140-Neural Pathways,
pubmed-meshheading:9425140-Peripheral Nerves,
pubmed-meshheading:9425140-Phenotype,
pubmed-meshheading:9425140-Protein Tyrosine Phosphatases,
pubmed-meshheading:9425140-Receptor-Like Protein Tyrosine Phosphatases, Class 4,
pubmed-meshheading:9425140-Receptors, Cell Surface,
pubmed-meshheading:9425140-rac GTP-Binding Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Drosophila Rac1 controls motor axon guidance.
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pubmed:affiliation |
Department of Cell Biology, Harvard Medical School, Boston, MA 02115-5730, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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