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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1998-1-21
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|
pubmed:abstractText |
Protamine reversal of heparin anticoagulation during cardiovascular surgery may cause severe hypotension and pulmonary hypertension. A novel protamine variant, [+18RGD], has been developed that effectively reverses heparin anticoagulation without toxicity in canine experiments. Heretofore, human studies have not been undertaken. This investigation hypothesized that [+18RGD] would effectively reverse heparin anticoagulation of human blood in vitro.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0741-5214
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|
pubmed:author |
pubmed-author:AndrewsP CPC,
pubmed-author:DoyleA RAR,
pubmed-author:HulinM SMS,
pubmed-author:JacobsL ALA,
pubmed-author:ShanleyC JCJ,
pubmed-author:StanleyJ CJC,
pubmed-author:StonehamM DMD,
pubmed-author:TenCateV MVM,
pubmed-author:WakefieldT WTW,
pubmed-author:WrobleskiS KSK,
pubmed-author:ZelenockG BGB
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|
pubmed:issnType |
Print
|
|
pubmed:volume |
26
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1043-8
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:9423721-Aged,
pubmed-meshheading:9423721-Blood Coagulation,
pubmed-meshheading:9423721-Blood Coagulation Factors,
pubmed-meshheading:9423721-Female,
pubmed-meshheading:9423721-Heparin Antagonists,
pubmed-meshheading:9423721-Humans,
pubmed-meshheading:9423721-Leukocyte Count,
pubmed-meshheading:9423721-Male,
pubmed-meshheading:9423721-Middle Aged,
pubmed-meshheading:9423721-Platelet Aggregation,
pubmed-meshheading:9423721-Platelet Count,
pubmed-meshheading:9423721-Protamines,
pubmed-meshheading:9423721-Vascular Surgical Procedures
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|
pubmed:year |
1997
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|
pubmed:articleTitle |
A novel protamine variant reversal of heparin anticoagulation in human blood in vitro.
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|
pubmed:affiliation |
Unit for Laboratory Animal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0329, USA.
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|
pubmed:publicationType |
Journal Article,
In Vitro
|
