Protamines

Source:http://linkedlifedata.com/resource/umls/id/C0033603

MSH: A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692),CSP: group of small (30-50 residues), arginine-rich nucleoproteins found sporadically throughout the phylogenetic kingdom; the USP drug, the sulfate salt, is used as an antidote to heparin.

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