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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-1-20
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pubmed:abstractText |
The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B-lymphocytes. Here, we provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via gp39/CD40L induced a strong activation of Jun-N-terminal kinase (JNK) and p38-K. Activation of these kinases correlates with a stimulation of Rac1 and inhibition of Rac1 prevents gp39/CD40L triggered JNK/p38-K activation. Further, cellular stimulation via the CD40 ligand results in tyrosine phosphorylation of cellular proteins and the activation of p56(lck). Inhibition of src-like kinases inhibits Rac1 as well as JNK/p38-K stimulation suggesting a signalling cascade from the gp39/CD40L via p56(lck) and Rac1 to JNK/p38-K.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/CD40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Specific Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
417
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9409738-Animals,
pubmed-meshheading:9409738-Antigens, CD,
pubmed-meshheading:9409738-Antigens, CD40,
pubmed-meshheading:9409738-CD40 Ligand,
pubmed-meshheading:9409738-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9409738-Humans,
pubmed-meshheading:9409738-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:9409738-Jurkat Cells,
pubmed-meshheading:9409738-Lymphocyte Activation,
pubmed-meshheading:9409738-Lymphocyte Specific Protein Tyrosine Kinase p56(lck),
pubmed-meshheading:9409738-Membrane Glycoproteins,
pubmed-meshheading:9409738-Mice,
pubmed-meshheading:9409738-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9409738-Recombinant Proteins,
pubmed-meshheading:9409738-Signal Transduction,
pubmed-meshheading:9409738-Spleen,
pubmed-meshheading:9409738-T-Lymphocytes,
pubmed-meshheading:9409738-Transfection,
pubmed-meshheading:9409738-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
1997
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pubmed:articleTitle |
Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes.
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pubmed:affiliation |
Department of Physiology, University of Tübingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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