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pubmed-article:9372055pubmed:abstractTextThis review summarizes recent findings concerning the role of CD40-ligand and CD40 interactions in B-cell differentiation. CD40-ligand on helper CD4+ T lymphocytes interacts with CD40 on B cells and directs the selection and differentiation of clones of B lymphocytes to generate specific antibody-dependent immune responses. CD40-ligand is necessary for normal B-cell differentiation and plays several distinctive roles in this multistage process. The CD40 signaling pathway that normally regulates B-cell death appears to be usurped by the Epstein-Barr virus to mediate B-cell transformation.lld:pubmed
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pubmed-article:9372055pubmed:articleTitleThe central role of the CD40-ligand and CD40 pathway in T-lymphocyte-mediated differentiation of B lymphocytes.lld:pubmed
pubmed-article:9372055pubmed:affiliationColumbia University, New York, NY 10032, USA.lld:pubmed
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