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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1997-12-23
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pubmed:abstractText |
This review summarizes recent findings concerning the role of CD40-ligand and CD40 interactions in B-cell differentiation. CD40-ligand on helper CD4+ T lymphocytes interacts with CD40 on B cells and directs the selection and differentiation of clones of B lymphocytes to generate specific antibody-dependent immune responses. CD40-ligand is necessary for normal B-cell differentiation and plays several distinctive roles in this multistage process. The CD40 signaling pathway that normally regulates B-cell death appears to be usurped by the Epstein-Barr virus to mediate B-cell transformation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1065-6251
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77-86
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9372055-Antigens, CD40,
pubmed-meshheading:9372055-B-Lymphocytes,
pubmed-meshheading:9372055-CD40 Ligand,
pubmed-meshheading:9372055-Cell Differentiation,
pubmed-meshheading:9372055-Humans,
pubmed-meshheading:9372055-Membrane Glycoproteins,
pubmed-meshheading:9372055-Models, Biological,
pubmed-meshheading:9372055-Neoplasms,
pubmed-meshheading:9372055-Signal Transduction,
pubmed-meshheading:9372055-T-Lymphocytes
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pubmed:year |
1996
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pubmed:articleTitle |
The central role of the CD40-ligand and CD40 pathway in T-lymphocyte-mediated differentiation of B lymphocytes.
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pubmed:affiliation |
Columbia University, New York, NY 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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