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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5 Pt 2
|
| pubmed:dateCreated |
1997-12-12
|
| pubmed:abstractText |
The impact of matching for the human leukocyte antigen (HLA)-DQ phenotype in cadaveric renal transplantation is unclear. We analyzed the effect of matching serologically defined HLA-DQ phenotypes on renal allograft survival in 12,050 first cadaveric renal transplants (recipients were 63.5% white and 36.5% African-American). Recipients were entered into the South-Eastern Organ Procurement Foundation (SEOPF) database between 1 October 1987 and 6 June 1995. A series of life table analyses were done to test the equality of survival curves for HLA-DQ match, both alone and accommodating for differences in recipient race and HLA-DR match. Cox regression models were then performed to detect differences in allograft survival based upon HLA-DQ match. Initial adjustments were done by recipient race. Subsequent adjustments were done by recipient and donor race, age and sex, cold ischemia time (CIT), body mass index (BMI), cyclosporine A (CyA) use, peak panel reactive antibody (PRA) titer, year of transplant, presence of diabetes mellitus (DM), and degree of HLA-A,B and HLA-DR match as covariates. The effect of varying degrees of HLA-DQ match on graft survival were similar between the two races (p = 0.87). In all recipients, an 8.3% reduction in graft failure was observed for each increase in HLA-DQ match using the Cox regression model adjusted only for recipient race (p = 0.004). A non-significant 3.0% reduction in graft failure (p = 0.38) was observed for each level of increasing HLA-DQ match when using the Cox regression model adjusted for recipient and donor race, age and sex, CIT, BMI, CyA use, year of transplant, DM, HLA-A,B and -DR match. In this model, superior HLA-A,B match and HLA-DR match, recipient and donor age, male donor sex, shorter CIT, white race of recipient, lower peak PRA, CyA use, and absence of DM significantly improved graft survival (all < or = 0.004). We conclude that HLA-DQ matching does not significantly affect cadaveric renal allograft survival once adjusted for other known predictors of graft outcome.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0902-0063
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
480-4
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9361945-African Continental Ancestry Group,
pubmed-meshheading:9361945-Age Factors,
pubmed-meshheading:9361945-Antibodies,
pubmed-meshheading:9361945-Body Mass Index,
pubmed-meshheading:9361945-Cadaver,
pubmed-meshheading:9361945-Cold Temperature,
pubmed-meshheading:9361945-Cyclosporine,
pubmed-meshheading:9361945-Databases as Topic,
pubmed-meshheading:9361945-Diabetes Mellitus,
pubmed-meshheading:9361945-European Continental Ancestry Group,
pubmed-meshheading:9361945-Female,
pubmed-meshheading:9361945-Forecasting,
pubmed-meshheading:9361945-Graft Survival,
pubmed-meshheading:9361945-HLA-A Antigens,
pubmed-meshheading:9361945-HLA-B Antigens,
pubmed-meshheading:9361945-HLA-DQ Antigens,
pubmed-meshheading:9361945-Histocompatibility,
pubmed-meshheading:9361945-Humans,
pubmed-meshheading:9361945-Immunosuppressive Agents,
pubmed-meshheading:9361945-Kidney Transplantation,
pubmed-meshheading:9361945-Life Tables,
pubmed-meshheading:9361945-Male,
pubmed-meshheading:9361945-Organ Preservation,
pubmed-meshheading:9361945-Phenotype,
pubmed-meshheading:9361945-Proportional Hazards Models,
pubmed-meshheading:9361945-Sex Factors,
pubmed-meshheading:9361945-Transplantation, Homologous,
pubmed-meshheading:9361945-Treatment Outcome
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
HLA-DQ matching in cadaveric renal transplantation.
|
| pubmed:affiliation |
Department of Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157-1053, USA.
|
| pubmed:publicationType |
Journal Article
|