|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
22
|
|
pubmed:dateCreated |
1997-12-4
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Mutant presenilins have been found to cause Alzheimer disease. Here, we describe the identification and characterization of HOP-1, a Caenorhabditis elegans presenilin that displays much more lower sequence identity with human presenilins than does the other C. elegans presenilin, SEL-12. Despite considerable divergence, HOP-1 appears to be a bona fide presenilin, because HOP-1 can rescue the egg-laying defect caused by mutations in sel-12 when hop-1 is expressed under the control of sel-12 regulatory sequences. HOP-1 also has the essential topological characteristics of the other presenilins. Reducing hop-1 activity in a sel-12 mutant background causes synthetic lethality and terminal phenotypes associated with reducing the function of the C. elegans lin-12 and glp-1 genes. These observations suggest that hop-1 is functionally redundant with sel-12 and underscore the intimate connection between presenilin activity and LIN-12/Notch activity inferred from genetic studies in C. elegans and mammals.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-1769331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-1935914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-2121610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-2498337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-2813415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-3005818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-3294421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-3581169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-3677168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-3677169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-4366476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-6546423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-6616618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-7108955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-7566091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-7567974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-7596406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-7638621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-7651536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-7758115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-8574969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-8755489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-8938132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-8938133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-8962160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-9153393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-9160754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9342387-9288750
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Glp-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lin-12 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SEL-12 protein, C elegans
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
28
|
|
pubmed:volume |
94
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
12204-9
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:9342387-Alzheimer Disease,
pubmed-meshheading:9342387-Amino Acid Sequence,
pubmed-meshheading:9342387-Animals,
pubmed-meshheading:9342387-Animals, Genetically Modified,
pubmed-meshheading:9342387-Caenorhabditis elegans,
pubmed-meshheading:9342387-Caenorhabditis elegans Proteins,
pubmed-meshheading:9342387-Cloning, Molecular,
pubmed-meshheading:9342387-DNA, Complementary,
pubmed-meshheading:9342387-Female,
pubmed-meshheading:9342387-Genes, Lethal,
pubmed-meshheading:9342387-Genetic Complementation Test,
pubmed-meshheading:9342387-Helminth Proteins,
pubmed-meshheading:9342387-Humans,
pubmed-meshheading:9342387-Membrane Glycoproteins,
pubmed-meshheading:9342387-Membrane Proteins,
pubmed-meshheading:9342387-Molecular Sequence Data,
pubmed-meshheading:9342387-Oviposition,
pubmed-meshheading:9342387-Phenotype,
pubmed-meshheading:9342387-Protein Conformation,
pubmed-meshheading:9342387-Sequence Analysis, DNA,
pubmed-meshheading:9342387-Sequence Homology, Amino Acid,
pubmed-meshheading:9342387-Signal Transduction,
pubmed-meshheading:9342387-Species Specificity
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.
|
|
pubmed:affiliation |
Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
