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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1997-10-22
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pubmed:abstractText |
Growth factors such as platelet-derived growth factor (PDGF) have been postulated to be important mediators of neointimal formation in balloon-injured artery. Binding of growth factors to their receptors activates intrinsic receptor tyrosine kinase, resulting in tyrosine phosphorylation of receptors themselves and cellular substrate proteins. We investigated in vivo activities of growth factors by determining the extent of tyrosine phosphorylation of growth factor receptors and substrate proteins in injured artery.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amlodipine,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Receptor Substrate Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Irs1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Angiotensin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/candesartan cilexetil
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0009-7322
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1906-13
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9323080-Amlodipine,
pubmed-meshheading:9323080-Angioplasty, Balloon,
pubmed-meshheading:9323080-Angiotensin II,
pubmed-meshheading:9323080-Angiotensin Receptor Antagonists,
pubmed-meshheading:9323080-Animals,
pubmed-meshheading:9323080-Antihypertensive Agents,
pubmed-meshheading:9323080-Benzimidazoles,
pubmed-meshheading:9323080-Biphenyl Compounds,
pubmed-meshheading:9323080-Calcium Channel Blockers,
pubmed-meshheading:9323080-Carotid Artery, Common,
pubmed-meshheading:9323080-Carotid Artery Injuries,
pubmed-meshheading:9323080-Insulin Receptor Substrate Proteins,
pubmed-meshheading:9323080-Male,
pubmed-meshheading:9323080-Phosphoproteins,
pubmed-meshheading:9323080-Phosphorylation,
pubmed-meshheading:9323080-Rats,
pubmed-meshheading:9323080-Rats, Wistar,
pubmed-meshheading:9323080-Receptor, Angiotensin, Type 1,
pubmed-meshheading:9323080-Receptor, Angiotensin, Type 2,
pubmed-meshheading:9323080-Receptor, Epidermal Growth Factor,
pubmed-meshheading:9323080-Receptor, Platelet-Derived Growth Factor alpha,
pubmed-meshheading:9323080-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:9323080-Receptors, Angiotensin,
pubmed-meshheading:9323080-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:9323080-Tetrazoles,
pubmed-meshheading:9323080-Tunica Intima,
pubmed-meshheading:9323080-Tyrosine
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pubmed:year |
1997
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pubmed:articleTitle |
Stimulated activation of platelet-derived growth factor receptor in vivo in balloon-injured arteries: a link between angiotensin II and intimal thickening.
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pubmed:affiliation |
Department of Cardiovascular Biology, Faculty of Medicine, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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