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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-11-6
|
| pubmed:abstractText |
In a randomized trial of 440 patients undergoing elective colorectal surgery, the prophylactic efficacy and the safety of amoxycillin/clavulanic acid were compared with that of a control regimen of clindamycin and gentamicin. Surgical wound healing was assessed by the ASEPSIS points scale; it was normal in 86% of patients and the scores for both groups were not statistically different (amoxycillin/clavulanic acid: 11.1; clindamycin + gentamicin: 10.9). Intra-abdominal infections were more frequent in the clindamycin + gentamicin arm of the study (Fisher's exact test, P = 0.035). It is concluded that amoxycillin/clavulanic acid is as effective and safe as clindamycin + gentamicin in the prevention of wound infection and may provide better protection against intra-abdominal infections.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0195-6701
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
55-64
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9321729-Adolescent,
pubmed-meshheading:9321729-Adult,
pubmed-meshheading:9321729-Aged,
pubmed-meshheading:9321729-Aged, 80 and over,
pubmed-meshheading:9321729-Amoxicillin-Potassium Clavulanate Combination,
pubmed-meshheading:9321729-Anti-Bacterial Agents,
pubmed-meshheading:9321729-Antibiotic Prophylaxis,
pubmed-meshheading:9321729-Clindamycin,
pubmed-meshheading:9321729-Colonic Diseases,
pubmed-meshheading:9321729-Cross Infection,
pubmed-meshheading:9321729-Drug Therapy, Combination,
pubmed-meshheading:9321729-Female,
pubmed-meshheading:9321729-Gentamicins,
pubmed-meshheading:9321729-Humans,
pubmed-meshheading:9321729-Male,
pubmed-meshheading:9321729-Middle Aged,
pubmed-meshheading:9321729-Postoperative Complications,
pubmed-meshheading:9321729-Prospective Studies,
pubmed-meshheading:9321729-Rectal Diseases,
pubmed-meshheading:9321729-Single-Blind Method,
pubmed-meshheading:9321729-Wound Healing
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Amoxycillin/clavulanic acid prophylaxis in elective colorectal surgery: a prospective randomized trial.
|
| pubmed:affiliation |
Department of Surgery, University Hospital (CHUV), Lausanne, Switzerland.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|