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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1997-10-30
|
| pubmed:abstractText |
The in-vitro activity of azithromycin, clarithromycin, erythromycin, josamycin, midekamycin, roxithromycin and clindamycin against 674 Gram-negative and Gram-positive clinical isolates, including methicillin-resistant Staphylococcus aureus, was determined by agar dilution, microdilution and agar diffusion with Mueller-Hinton medium according to the Deutsches Institut für Normung (DIN) 58940 guidelines. The results obtained by regression analysis and the error-rate-bounded method of Metzler-DeHaan indicate that common interpretative criteria (breakpoints) for test discs may be assigned to susceptible/resistant Gram-positive strains for all antibiotics tested. The following tentative DIN values are suggested for 15 microg macrolide discs: for susceptible Gram-positive and Gram-negative strains, an inhibition zone diameter (IZD) of > or = 26 mm at a corresponding MIC of < or = 2 mg/L; for resistant Gram-positive strains, an IZD of < or = 21 mm; for resistant Gram-negative strains, an IZD of < or = 19 mm at a corresponding MIC of > or = 8 mg/L. For Haemophilus influenzae only, breakpoints for azithromycin are suggested with IZDs of > or = 21 mm for susceptible and < or = 18 mm for resistant.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0305-7453
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
179-87
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9301982-Anti-Bacterial Agents,
pubmed-meshheading:9301982-Dose-Response Relationship, Drug,
pubmed-meshheading:9301982-Gram-Negative Bacteria,
pubmed-meshheading:9301982-Gram-Positive Bacteria,
pubmed-meshheading:9301982-Guidelines as Topic,
pubmed-meshheading:9301982-Haemophilus influenzae,
pubmed-meshheading:9301982-Humans,
pubmed-meshheading:9301982-Lincosamides,
pubmed-meshheading:9301982-Macrolides,
pubmed-meshheading:9301982-Methicillin Resistance,
pubmed-meshheading:9301982-Microbial Sensitivity Tests,
pubmed-meshheading:9301982-Staphylococcus aureus
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Susceptibility testing of macrolide and lincosamide antibiotics according to DIN guidelines. Deutsches Institut für Normung.
|
| pubmed:affiliation |
Microbiology Laboratories Research & Development, Pfizer/Mack, H. Mack Nachf., Illertissen, Germany.
|
| pubmed:publicationType |
Journal Article
|