Linked Life Data

9299586

Source:http://linkedlifedata.com/resource/pubmed/id/9299586

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-10-28
pubmed:abstractText
Embryonic dorsoventral polarity in Drosophila melanogaster is determined by a maternally-encoded signal transduction pathway whose effector molecule is the Rel transcription factor, Dorsal. The activity of this signal transduction pathway gives rise to a ventral-to-dorsal nuclear gradient of Dorsal, which then activates and represses several zygotic target genes in distinct domains. The dorsoventral system represents the best characterized of the Rel pathways. Its components have now been ordered and their biochemical roles are becoming clearer. Key components of the dorsoventral pathway show striking similarity to those involved with the regulation of vertebrate Rel family members. Additional Drosophila Rel family members have been identified and implicated in the innate immune response. The dorsoventral pathway is also remarkably conserved in this response. This conservation underscores the relevance of the dorsoventral system for our understanding of the entire Rel family.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1044-579X
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-92
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
The dorsoventral signal transduction pathway and the Rel-like transcription factors in Drosophila.
pubmed:affiliation
Department of Molecular Biology, Princeton University, NJ 08544, USA.
pubmed:publicationType
Journal Article, Review