| pubmed-article:9271462 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9271462 | lifeskim:mentions | umls-concept:C0006069 | lld:lifeskim |
| pubmed-article:9271462 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9271462 | lifeskim:mentions | umls-concept:C0012550 | lld:lifeskim |
| pubmed-article:9271462 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:9271462 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9271462 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9271462 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:9271462 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9271462 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9271462 | pubmed:dateCreated | 1997-10-15 | lld:pubmed |
| pubmed-article:9271462 | pubmed:abstractText | A plasmid pLTR-DT which contained a gene for diphtheria toxin A-chain (DT-A) under the control of the long terminal repeat (LTR) of bovine leukemia virus (BLV) (BLV-LTR) in the multicloning site of pUC-18 was entrapped in cationic liposomes composed of N-(alpha-trimethylammonioacetyl)-didodecyl-D-glutamate chloride (TMAG), dioleoyl phosphatidylethanolamine (DOPE) and dilauroyl phosphatidylcholine (DLPC) (1:2:2, molar ratio) (TMAG-liposome), and their antitumor effect on BLV-infected tumor cells was examined in vivo. The cationic TMAG-liposome containing pLTR-DT was successively injected into the tumor transplanted to nude mice. The growth of tumor was significantly inhibited by the injection of cationic TMAG-liposome containing pLTR-DT. On the other hand, TMAG-liposome containing pUC18 plasmids showed no such effect. These results suggest that a DT-A expression plasmid under the control of BLV-LTR is highly toxic to the BLV-infected tumor cells, and that the cationic liposomes, such as TMAG-liposome, may be efficient transfection reagent for BLV-infected tumor cells and can be utilized for DT-A gene delivery into BLV-infected tumor cells in vivo. | lld:pubmed |
| pubmed-article:9271462 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9271462 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9271462 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9271462 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9271462 | pubmed:issn | 0916-7250 | lld:pubmed |
| pubmed-article:9271462 | pubmed:author | pubmed-author:KeyI DID | lld:pubmed |
| pubmed-article:9271462 | pubmed:author | pubmed-author:OnumaMM | lld:pubmed |
| pubmed-article:9271462 | pubmed:author | pubmed-author:YasudaTT | lld:pubmed |
| pubmed-article:9271462 | pubmed:author | pubmed-author:OchiaiKK | lld:pubmed |
| pubmed-article:9271462 | pubmed:author | pubmed-author:TappMM | lld:pubmed |
| pubmed-article:9271462 | pubmed:author | pubmed-author:WataraiSS | lld:pubmed |
| pubmed-article:9271462 | pubmed:author | pubmed-author:KakidaniHH | lld:pubmed |
| pubmed-article:9271462 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9271462 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:9271462 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9271462 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9271462 | pubmed:pagination | 617-9 | lld:pubmed |
| pubmed-article:9271462 | pubmed:dateRevised | 2006-5-1 | lld:pubmed |
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| pubmed-article:9271462 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9271462 | pubmed:articleTitle | In vivo antitumor effect of cationic liposomes containing diphtheria toxin A-chain gene on cells infected with bovine leukemia virus. | lld:pubmed |
| pubmed-article:9271462 | pubmed:affiliation | Department of Cell Chemistry, Institute of Cellular and Molecular Biology, Okayama University Medical School, Japan. | lld:pubmed |
| pubmed-article:9271462 | pubmed:publicationType | Journal Article | lld:pubmed |
