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rdf:type |
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lifeskim:mentions |
umls-concept:C0013138,
umls-concept:C0014520,
umls-concept:C0017262,
umls-concept:C0185117,
umls-concept:C0221920,
umls-concept:C0242697,
umls-concept:C0574895,
umls-concept:C0584655,
umls-concept:C0871261,
umls-concept:C1332838,
umls-concept:C1704336,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1959633,
umls-concept:C2346501,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
16
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pubmed:dateCreated |
1997-9-8
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pubmed:abstractText |
The egr-type zinc-finger transcription factor encoded by the Drosophila gene stripe (sr) is expressed in a subset of epidermal cells to which muscles attach during late stages of embryogenesis. We report loss-of-function and gain-of-function experiments indicating that sr activity provides ectodermal cells with properties required for the establishment of a normal muscle pattern during embryogenesis and for the differentiation of tendon-like epidermal muscle attachment sites (EMA). Our results show that sr encodes a transcriptional activator which acts as an autoregulated developmental switch gene. sr activity controls the expression of EMA-specific target genes in cells of ectodermal but not of mesodermal origin. sr-expressing ectodermal cells generate long-range signals that interfere with the spatial orientation of the elongating myotubes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-1673924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-1902805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-1903298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-2100994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-2331752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-2476281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-2878369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-3917855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-6289436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-7441148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-7441159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-7600995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-7732594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-8119132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-8196652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-8223268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-8334991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-8612588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9238024-8951053
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8606-11
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9238024-Animals,
pubmed-meshheading:9238024-DNA-Binding Proteins,
pubmed-meshheading:9238024-Drosophila,
pubmed-meshheading:9238024-Drosophila Proteins,
pubmed-meshheading:9238024-Epidermis,
pubmed-meshheading:9238024-Gene Expression Regulation, Developmental,
pubmed-meshheading:9238024-Genes, Insect,
pubmed-meshheading:9238024-Muscle, Skeletal,
pubmed-meshheading:9238024-Transcription Factors
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pubmed:year |
1997
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pubmed:articleTitle |
Epidermal muscle attachment site-specific target gene expression and interference with myotube guidance in response to ectopic stripe expression in the developing Drosophila epidermis.
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pubmed:affiliation |
Max-Planck-Institut für biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Am Fassberg, D-37077 Göttingen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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