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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1997-8-15
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pubmed:abstractText |
We have characterized mutations in the Drosophila homolog of the mammalian proto-oncogene c-Jun gene (Djun). We demonstrate that DJUN in the embryo is a downstream target of the JNK signal transduction pathway during dorsal closure formation, and that the function of the JNK/DJUN pathway is to control the localized expression of decapentalegic (dpp), a member of the TGF-beta growth factor family. In contrast to previous observations, we find that both in the embryo and during photoreceptor cell determination, DJUN is not regulated by a pathway that involves MAPK.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-jun,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/dpp protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/sev protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1728-37
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9224721-Animals,
pubmed-meshheading:9224721-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9224721-Cell Differentiation,
pubmed-meshheading:9224721-Drosophila,
pubmed-meshheading:9224721-Drosophila Proteins,
pubmed-meshheading:9224721-Epithelial Cells,
pubmed-meshheading:9224721-Eye Proteins,
pubmed-meshheading:9224721-Gene Expression Regulation, Developmental,
pubmed-meshheading:9224721-Genes, Insect,
pubmed-meshheading:9224721-Insect Proteins,
pubmed-meshheading:9224721-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:9224721-Membrane Glycoproteins,
pubmed-meshheading:9224721-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9224721-Mutation,
pubmed-meshheading:9224721-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:9224721-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:9224721-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:9224721-Signal Transduction
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pubmed:year |
1997
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pubmed:articleTitle |
Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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