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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1997-8-7
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pubmed:abstractText |
Twin concordance studies suggest that genetic factors play a role in determining why only a minority of heavy drinkers develop hepatitis and cirrhosis. Tumor necrosis factor alpha (TNF-alpha) has emerged as the "final common pathway" in the pathogenesis of alcohol-related hepatic necro-inflammation. We have examined the frequency of the two recently described polymorphisms of the TNF-alpha promoter in 150 patients with biopsy-proven alcoholic liver disease and 145 healthy volunteers. There was a significant excess of the rare allele (TNFA-A; G(-238) --> A) at position -238 in patients with steatohepatitis compared with controls or patients without this lesion. This is consistent with previous suggestions that the TNFA-A allele, which falls within a putative Y regulation box of the TNF-alpha promoter, is associated with increased TNF-alpha expression. No differences were observed for the polymorphism at position -308.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0270-9139
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
143-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9214463-Age Factors,
pubmed-meshheading:9214463-Hepatitis, Alcoholic,
pubmed-meshheading:9214463-Humans,
pubmed-meshheading:9214463-Liver Cirrhosis, Alcoholic,
pubmed-meshheading:9214463-Polymorphism, Genetic,
pubmed-meshheading:9214463-Promoter Regions, Genetic,
pubmed-meshheading:9214463-Sex Factors,
pubmed-meshheading:9214463-Tumor Necrosis Factor-alpha
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pubmed:year |
1997
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pubmed:articleTitle |
Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis.
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pubmed:affiliation |
Department of Medicine, University of Newcastle, Newcastle upon Tyne, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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