Linked Life Data

9209449

Source:http://linkedlifedata.com/resource/pubmed/id/9209449

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-8-7
pubmed:abstractText
The overexpression of PRAD1/cyclin D1 gene activated by the 11q13 translocation and its molecular counterpart BCL-1 rearrangement is frequently associated with mantle cell lymphomas (MCLs). Recently, we produced a monoclonal antibody, 5D4, against the PRAD1/cyclin D1 product, and demonstrated that the positive nuclear staining by this antibody correlates with PRAD1/cyclin D1 mRNA overexpression in MCLs. In the present study, we have immunohistochemically examined the cyclin D1 protein in a large series of 315 malignant lymphomas including 39 MCLs on paraffin sections. The nuclear positive pattern was found in 35 (90%) of 39 MCLs with an exceptional case of immunocytoma among the B-cell lymphomas examined. In the other cases, the positivity was absent or appeared to lie within the cytoplasm without nuclear staining. We therefore propose that the immunolocalization of cyclin D1 protein is an essential marker for the definite diagnosis of MCL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0887-6924
pubmed:author
pubmed:issnType
Print
pubmed:volume
11 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
536-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Immunostaining of PRAD1/cyclin D1 protein as a marker for the diagnosis of mantle cell lymphoma.
pubmed:affiliation
Department of Pathology, Aichi Cancer Center Hospital, Nagoya, Japan.
pubmed:publicationType
Journal Article