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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1997-7-17
|
| pubmed:abstractText |
Cell lineage analysis with retroviral libraries suggests that clonal progeny disperse widely in rodent cortex. To determine whether widespread dispersion is a general mammalian plan and to investigate phylogenetic differences in cortical development, we analyzed cell lineage in the ferret, a carnivore and near relative of the cat. The ferret possesses a highly developed, folded cerebral cortex, characteristic of higher mammalian species. Progenitor cells of the ferret cerebral cortex were tagged with an amphotropic retroviral library encoding alkaline phosphatase, and sibling relationships were determined using the polymerase chain reaction. Neuronal clones were single neurons (52%) or large clones (48%; average, 7 neurons) containing neurons and glia in widespread cortical locations. Neuronal clones in the ferret labeled at middle to late neurogenesis (embryonic day 33-35) contained large numbers of neurons and showed little tendency to cluster. The large proportion of single neuron clones, contrasted with the large size of multicell clones, suggests that some progenitors divide asymmetrically, producing a postmitotic neuron and regenerating a multipotential cell.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0950-1991
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
124
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2441-50
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9199370-Alkaline Phosphatase,
pubmed-meshheading:9199370-Animals,
pubmed-meshheading:9199370-Cell Differentiation,
pubmed-meshheading:9199370-Cell Division,
pubmed-meshheading:9199370-Cerebral Cortex,
pubmed-meshheading:9199370-Clone Cells,
pubmed-meshheading:9199370-Embryonic Induction,
pubmed-meshheading:9199370-Female,
pubmed-meshheading:9199370-Ferrets,
pubmed-meshheading:9199370-Gestational Age,
pubmed-meshheading:9199370-Models, Biological,
pubmed-meshheading:9199370-Neurons,
pubmed-meshheading:9199370-Phenotype,
pubmed-meshheading:9199370-Polymerase Chain Reaction,
pubmed-meshheading:9199370-Pregnancy,
pubmed-meshheading:9199370-Retroviridae,
pubmed-meshheading:9199370-Staining and Labeling,
pubmed-meshheading:9199370-Stem Cells
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Clonal dispersion and evidence for asymmetric cell division in ferret cortex.
|
| pubmed:affiliation |
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|