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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6634
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pubmed:dateCreated |
1997-7-9
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pubmed:databankReference |
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pubmed:abstractText |
Neurturin (NTN) is a recently identified homologue of glial-cell-line-derived neurotrophic factor (GDNF). Both factors promote the survival of a variety of neurons, and GDNF is required for the development of the enteric nervous system and kidney. GDNF signals through a receptor complex consisting of the receptor tyrosine kinase Ret and a glycosyl-phosphatidylinositol (GPI)-linked receptor termed GDNFR-alpha. Here we report the cloning of a new GPI-linked receptor termed NTNR-alpha that is homologous with GDNFR-alpha and is widely expressed in the nervous system and other tissues. By using microinjection to introduce expression plasmids into neurons, we show that coexpression of NTNR-alpha with Ret confers a survival response to neurturin but not GDNF, and that coexpression of GDNFR-alpha with Ret confers a survival response to GDNF but not neurturin. Our findings indicate that GDNF and neurturin promote neuronal survival by signalling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Gdnf protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Cell Line-Derived...,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Cell Line-Derived...,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosylphosphatidylinositols,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neurturin,
http://linkedlifedata.com/resource/pubmed/chemical/Nrtn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ret,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Ret oncogene protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Ret protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
387
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
721-4
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pubmed:dateRevised |
2010-8-25
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pubmed:meshHeading |
pubmed-meshheading:9192899-Amino Acid Sequence,
pubmed-meshheading:9192899-Animals,
pubmed-meshheading:9192899-Blotting, Northern,
pubmed-meshheading:9192899-Cell Survival,
pubmed-meshheading:9192899-Cells, Cultured,
pubmed-meshheading:9192899-Chick Embryo,
pubmed-meshheading:9192899-Cloning, Molecular,
pubmed-meshheading:9192899-Drosophila Proteins,
pubmed-meshheading:9192899-Glial Cell Line-Derived Neurotrophic Factor,
pubmed-meshheading:9192899-Glial Cell Line-Derived Neurotrophic Factor Receptors,
pubmed-meshheading:9192899-Glycosylphosphatidylinositols,
pubmed-meshheading:9192899-Ligands,
pubmed-meshheading:9192899-Mice,
pubmed-meshheading:9192899-Molecular Sequence Data,
pubmed-meshheading:9192899-Nerve Growth Factors,
pubmed-meshheading:9192899-Nerve Tissue Proteins,
pubmed-meshheading:9192899-Neurons,
pubmed-meshheading:9192899-Neurturin,
pubmed-meshheading:9192899-Nodose Ganglion,
pubmed-meshheading:9192899-Proto-Oncogene Proteins,
pubmed-meshheading:9192899-Proto-Oncogene Proteins c-ret,
pubmed-meshheading:9192899-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:9192899-Receptors, Cell Surface,
pubmed-meshheading:9192899-Signal Transduction,
pubmed-meshheading:9192899-Superior Cervical Ganglion,
pubmed-meshheading:9192899-Type C Phospholipases
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pubmed:year |
1997
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pubmed:articleTitle |
Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.
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pubmed:affiliation |
School of Biological and Medical Sciences, University of St Andrews, Fife, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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