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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
1
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pubmed:dateCreated |
1997-10-2
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pubmed:abstractText |
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0171-967X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9192515-Bone Diseases,
pubmed-meshheading:9192515-Clodronic Acid,
pubmed-meshheading:9192515-Collagen,
pubmed-meshheading:9192515-Collagenases,
pubmed-meshheading:9192515-Dose-Response Relationship, Drug,
pubmed-meshheading:9192515-Fibroblasts,
pubmed-meshheading:9192515-Humans,
pubmed-meshheading:9192515-Jaw Cysts,
pubmed-meshheading:9192515-Matrix Metalloproteinase 1,
pubmed-meshheading:9192515-Matrix Metalloproteinase 8
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pubmed:year |
1997
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|
pubmed:articleTitle |
Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate).
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pubmed:affiliation |
Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Helsinki, P.O. Bos 41 (Mannerheimintie 172) FIN-00014, Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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