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rdf:type |
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lifeskim:mentions |
umls-concept:C0004461,
umls-concept:C0013138,
umls-concept:C0018787,
umls-concept:C0026845,
umls-concept:C0205127,
umls-concept:C0442045,
umls-concept:C0927232,
umls-concept:C1185740,
umls-concept:C1514873,
umls-concept:C1522492,
umls-concept:C1995013
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pubmed:issue |
11
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pubmed:dateCreated |
1997-7-9
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pubmed:abstractText |
DFR1 encodes a mesoderm-specific fibroblast growth factor receptor in Drosophila. Here, we identified and characterized a protein-null mutant of DFR1 and examined DFR1 expression in embryos using anti-DFR1 antibody. Mutant phenotypes were completely rescued by a genomic fragment from the DFR1 locus. After invagination, mesodermal cells expressing DFR1 undergo proliferation and spread out dorsally to form a monolayer beneath the ectoderm. In mutant embryos, however, the mesoderm is not capable of extending to the normal dorsal limit and consequently mesodermal cells fail to receive ectodermal signals and thus rendered incapable of differentiating into primordia for the heart, visceral and somatic muscles. DFR1 is also required for normal development of the central nervous system. The absence of DFR1 resulted in the failure of longitudinal glia to enwrap longitudinal axon tracts. DFR1 mutant phenotypes were partially mimicked by the targeted expression of activated Yan, thus demonstrating the MAP kinase pathway to be involved in differentiation of mesoderm.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules, Neuronal,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fas3 (fasciclin 3) protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fibroblast Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/anterior open protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/heartless protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/hedgehog protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/wg protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0950-1991
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2119-28
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9187139-Abdomen,
pubmed-meshheading:9187139-Animals,
pubmed-meshheading:9187139-Axons,
pubmed-meshheading:9187139-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9187139-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:9187139-Cell Differentiation,
pubmed-meshheading:9187139-Cell Movement,
pubmed-meshheading:9187139-Central Nervous System,
pubmed-meshheading:9187139-DNA-Binding Proteins,
pubmed-meshheading:9187139-Drosophila,
pubmed-meshheading:9187139-Drosophila Proteins,
pubmed-meshheading:9187139-Eye Proteins,
pubmed-meshheading:9187139-Gene Expression Regulation, Developmental,
pubmed-meshheading:9187139-Heart,
pubmed-meshheading:9187139-Hedgehog Proteins,
pubmed-meshheading:9187139-Insect Proteins,
pubmed-meshheading:9187139-Mesoderm,
pubmed-meshheading:9187139-Muscles,
pubmed-meshheading:9187139-Mutation,
pubmed-meshheading:9187139-Neuroglia,
pubmed-meshheading:9187139-Protein-Tyrosine Kinases,
pubmed-meshheading:9187139-Proto-Oncogene Proteins,
pubmed-meshheading:9187139-Receptors, Fibroblast Growth Factor,
pubmed-meshheading:9187139-Repressor Proteins,
pubmed-meshheading:9187139-Restriction Mapping,
pubmed-meshheading:9187139-Signal Transduction,
pubmed-meshheading:9187139-Wnt1 Protein
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pubmed:year |
1997
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pubmed:articleTitle |
Requirements of DFR1/Heartless, a mesoderm-specific Drosophila FGF-receptor, for the formation of heart, visceral and somatic muscles, and ensheathing of longitudinal axon tracts in CNS.
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pubmed:affiliation |
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo-ku, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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